Lead investigator discusses a new study that assessed APOCIII -Lrx's efficacy and safety in reducing apolipoprotein C-III and triglycerides ... ... <看更多>
ApoC-III raises plasma triglycerides through inhibition of LPL, stimulation of VLDL secretion, and is a novel factor in modulating intestinal triglyceride ...
ApoC-III is a relatively small protein containing 79 amino acids that can be glycosylated at threonine-74. ... The most abundant glycoforms are characterized by ...
Apolipoprotein CIII (ApoCIII) is one of the most abundant apolipoproteins in the blood, where it is present as an exchangeable component between high-density ...
Apolipoprotein CIII (apoCIII) was first identified more than 40 years ago as a component of very-low-density lipoprotein (VLDL)1 and shortly thereafter as ...
Home » Research Programs » Serum factor apoCIII » ApoCIII. Biocrine AB. Box 3073. 169 03 Solna, Sweden. Contact Us. info at biocrine.se · www.biocrine.com.
The current study demonstrates that ApoC-III is a prominent component of Lp(a) and has strong immunological presence in aortic valve leaflets and co-localises ...
An increase in apoC-III levels induces the development of hypertriglyceridemia. [provided by RefSeq, Jul 2008] Apolipoprotein CIII (ApoCIII) is a component of ...
#12.
Apolipoprotein CIII predicts cardiovascular events in patients ...
Apolipoprotein CIII (apoCIII) is associated with triglyceride-rich lipoprotein metabolism and has emerged as independent marker for risk of ...
#13.
Effects of Fructose or Glucose on Circulating ApoCIII ... - MDPI
We measured apoCIII concentrations and the TG and cholesterol content of lipoprotein subfractions separated by size in fasting and postprandial plasma collected ...
#14.
Study of ISIS 678354 (AKCEA-APOCIII-LRx) in Participants ...
Study of ISIS 678354 (AKCEA-APOCIII-LRx) in Participants With Hypertriglyceridemia and Established Cardiovascular Disease (CVD) ...
#15.
APOCIII-LRX Reduces Triglyceride Levels in High CV Risk ...
A previous phase 1 study assessed the effects of APOCIII-L RX in ... the drug showed dose-dependent reductions in apoC-III, triglycerides, ...
#16.
Changes in the Ratios of the Hdl-Apociii to ... - NTU Scholars
Title: Changes in the Ratios of the Hdl-Apociii to Plasma-Apociii Associated with an Increased Risk of Coronary Artery Disease. Authors: LEE, YUAN-TEH
#17.
Apociii and apoa5 in healthy subjects as regulators of ...
So far, the roles of both apoCIII and apoA5 on postprandial lipid metabolism are less well established. Methods: We studied 67 healthy normoglycemic subjects ( ...
#18.
Apolipoprotein CIII (ApoCIII) Protein - MyBioSource
#19.
Uncovering the role of apolipoprotein C-III in insulin resistance
Apolipoprotein C-III (apoC-III) is a small protein that is predominantly synthesized in the liver and mainly resides at the surface of triglyceride-rich ...
#20.
Olezarsen | Ionis Pharmaceuticals, Inc.
Olezarsen, formerly known as IONIS-APOCIII-LRx and AKCEA-APOCIII-LRx, ... medicine designed to inhibit the production of apoC-III for patients who are at ...
#21.
ApoCIII inhibitors - Triglyceride Forum
Volanesorsen is an antisense oligonucleotide that inhibits the production of apoCIII. It is currently indicated as an adjunct to diet in adult patients with ...
#22.
apoC-III Antibody (8H7) | SCBT - Santa Cruz Biotechnology
apoC-III Antibody (8H7) is an IgG2a κ mouse monoclonal apoC-III antibody that detects human apoC-III by WB, IP, IF and ELISA. 2 citations.
#23.
ApoC-III inhibits clearance of triglyceride-rich lipoproteins ... - JCI
ASO reduction of ApoC-III had no effect on VLDL secretion, heparin-induced TG reduction, or uptake of lipids into heart and skeletal muscle. Our ...
#24.
save - Sci-Hub
Aggravated restenosis and atherogenesis in ApoCIII transgenic mice but lack of protection in ApoCIII knockouts: the effect of authentic triglyceride-rich ...
#25.
Positive Phase 2 Clinical Data of AKCEA-APOCIII ... - BioSpace
Positive Phase 2 Clinical Data of AKCEA-APOCIII-L(Rx) Presented at ESC Congress 2020 - read this article along with other careers ...
#26.
CD14+-单核细胞暴露于载脂蛋白CIII 表达组织因子。 - X-MOL
Apolipoprotein CIII (ApoCIII) represents a key regulator of plasma lipid metabolism and a recognized risk factor for atherosclerosis and ...
#27.
Modulation of apolipoprotein CIII (ApoCIII) expression
Provided herein are methods, compounds, and compositions for reducing expression of ApoCIII mRNA and protein in an animal. Also provided herein are methods, ...
#28.
ApoCIII enrichment in HDL impairs HDL-mediated ... - Nature
Apolipoprotein CIII (apoCIII) has been reported to be tightly associated with triglyceride metabolism and the susceptibility to coronary ...
#29.
ApoCIII-Enriched LDL in Type 2 Diabetes Displays Altered ...
OBJECTIVE. Apolipoprotein CIII (apoCIII) is an independent risk factor for cardiovascular disease, but the molecular mechanisms involved are ...
#30.
Glucose induces apoCIII expression and promoter activity in ...
C, Dose dependence of glucose-induced apoCIII mRNA expression in IHH after 24 ... Apolipoprotein CIII (apoCIII), a regulator of hepatic and plasma triglyceride.
#31.
A Regulatory Element in the ApoCIII Promoter That Directs ...
A variety of murine tissue types, includ- ing those that do not express the apoCIII gene, were found to contain C3P binding proteins. We ...
#32.
opposing roles of apoE and apoCIII - Harvard DASH
Morton, Allyson Michelle. 2018. Dietary unsaturated fat improves high density lipoprotein function: opposing roles of apoE and apoCIII. Doctoral dissertation, ...
#33.
Life is complicated: so is apoCIII 1 - Journal of Lipid Research
Overexpression of apoCIII and targeted deletion of the APOC3 gene in mice confirmed the human findings as well as the earlier rodent studies ...
#34.
Human Apolipoprotein Mutants 2: From Gene Structure to ...
This comparison showed that 9 nucleotides in the apoAI gene exon 4 (AGACAGAGG) and 21 nucleotides in the apoCIII gene intron 1 (CCCAGTCCTACCCCAGACAGG) have ...
#35.
Reduction in lipoprotein-associated apoC-III levels following ...
Reduction in lipoprotein-associated apoC-III levels following volanesorsen therapy: phase 2 randomized trial results1 [2016]. Xiaohong Yang; Sang-Rok Lee; ...
#36.
Aggravated restenosis and atherogenesis in ApoCIII ... - Scite
Supporting: 2, Mentioning: 33 - Severe hypertriglyceridaemia resulting from ApoCIII overexpression promotes restenosis and atherosclerosis.
#37.
The part played by Apolipoprotein CIII in diabetes
We've also found that apoCIII is linked to overweight, insulin sensitivity and the development of type 2 diabetes.” Professor Juntti-Berggren's ...
#38.
The association of HDL-apoCIII with coronary heart disease ...
Total plasma apoCIII, especially HDL-apoCIII was significantly elevated after statin treatment in CHD patients, whereas total cholesterol (TC), low density ...
#39.
Full article: Targeting apoC-III and ANGPTL3 in the treatment ...
Both apolipoprotein C-III (apoC-III) and angiopoietin-like 3 (ANGPTL3) are important regulators in TG-rich lipoprotein (TRL) metabolism. Several novel agents ...
#40.
Is apoCIII-Lowering A Double-Edged Sword? - J-Stage
Is apoCIII-Lowering A Double-Edged Sword? Xiangming Tang, Huanjin Zhou, Haizhao Yan, Manabu Niimi, Jianglin Fan.
#41.
Apolipoprotein CIII (ApoCIII), Human - Ultra Pure
Apolipoprotein CIII (ApoCIII), Human - Ultra Pure · Catalog Number: 125-21 · Custom Quote · Product Citations ...
#42.
Secretion of lipid‐poor nascent human apolopoprotein apoAI ...
Abstract The human apolipoprotein apoAI, apoCIII, and apoE genes were placed under the control of the mouse metallothionein 1 promoter in a bovine papilloma ...
#43.
A study on the diabetogenic and cardiovascular risk ... - DR-NTU
Apolipoprotein C3 (ApoCIII) has been heavily associated with promoting inflammatory responses in cardiovascular disease and atherosclerosis. Recently, there has ...
#44.
ApoC-III inhibition reduces triglycerides in patients at high risk ...
Olezarsen is a (GalNAc)-conjugated, antisense oligonucleotide targeted to hepatic //APOC3// mRNA to inhibit apoC-III.
#45.
the effect of authentic triglyceride-rich lipoproteins with and ...
ApoCIII transgenic (ApoCIIItg) and knockout (ApoCIII−/−) mice underwent endothelial denudation to model restenosis. Here, ApoCIIItg mice displayed severe ...
#46.
ApoC-III overexpression and LDLr-/- protect mice from DSS ...
Tregs exposed to apoC-III increase lipolysis and fatty acid oxidation and apoC-III inhibits Bodipy-triglyceride uptake. Therapeutic treatment of ...
#47.
Human ApoCIII ELISA Kit
ApoCIII inhibits the hydrolysis of TG-rich particles by the lipoprotein lipase and their hepatic uptake mediated by ApoE. Figure 1: Structure of ...
#48.
Apolipoprotein Ciii 載脂蛋白Ciii
Apolipoprotein CIII (apoCIII) is an important modulator of hepatic production and peripheral removal of triglycerides. 載脂蛋白CIII (apoCIII) 是肝臟產生和 ...
#49.
BRIEF-Akcea Says Retained Rights To Develop And ... - Reuters
... TO EXERCISE ITS OPTION, CO RETAINED RIGHTS TO DEVELOP AND COMMERCIALIZE AKCEA-APOCIII-LRX Source text for Eikon: Further company coverage:
#50.
Apolipoprotein CIII promotes Ca2+-dependent β cell death in ...
The apoCIII-induced increase in [Ca 2+ ]i reflects an activation of the voltage-gated L-type Ca 2+ channel. Both the effects of T1D sera and apoCIII on the β cell ...
#51.
Positive Phase 2 Clinical Data of AKCEA ... - PR Newswire
Significant reductions in apoC-III (up to 74%) and atherogenic lipoproteins including very low-density lipoprotein (VLDL) cholesterol (60%), non ...
#52.
The Positive Association between Plasma Myristic Acid and ...
#57.
Cardiovascular Disease: From Molecular Mechanisms to ...
Discussion In the present study, we explored differences between circulating apoCIII and the TG and chol composition of lipoprotein fractions in subjects ...
#58.
Advances in Human Genetics 21 - 第 228 頁 - Google 圖書結果
The dissociation constant K, of apoCIII from model lipid emulsions (microemulsions and large emulsions containing egg yolk lecithin and triolein) ranges ...
Like T1D sera, ApoCIII markedly increases whole-cell CaV channel currents and [Ca2+] i in the β cell and prominently provokes β cell apoptosis.
#60.
Jean-Claude Tardif, MD: APOCIII-Lrx and CV Risk Reduction
Lead investigator discusses a new study that assessed APOCIII -Lrx's efficacy and safety in reducing apolipoprotein C-III and triglycerides ...
#61.
ApoAV Counteracts ApoCIII in Improving Hypertriglyceridemia
ApoAV Counteracts ApoCIII in Improving Hypertriglyceridemia ... To investigate this functional dichotomy of ApoA-V and ApoC-III in TG metabolism, ...
#62.
不用管住嘴也能保持代谢健康？靶向ApoCIII或有奇效| 热心肠日报
① 反义疗法（ASO）降低高脂饮食（HFD）导致肥胖小鼠的ApoCIII可以增强氧化呼吸，改善其代谢状态；② 降低apoCIII可以影响棕色脂肪组织（BAT），改善葡萄糖稳态和 ...
#63.
Contribution of ApoCIII to Diabetic Dyslipidemia and ...
Mechanisms underlying insulin resistance-induced diabetic dyslipidemia seem to be re- lated to apolipoprotein CIII (ApoCIII), a known inhibitor ...
#64.
Ultra Pure Human Apolipoprotein CIII (ApoCIII) from Academy ...
Ultra Pure Human Apolipoprotein CIII (ApoCIII) 33P-UP210 from Academy Biomedical Company, Inc.
#65.
Inhibition of ApoCIII: the next PCSK9? - Lippincott
Recent large Mendelian randomization studies associate loss-of-function mutations in apolipoprotein CIII (APOCIII) with low levels of triglycerides and ...
#66.
Late-Breaking Science: Lowering triglycerides with antisense ...
Given their key role in triglyceride (TG) metabolism, apolipoprotein C-III (apoC-III) and angiopoietin-like 3 (ANGPTL3) are being ...
#67.
Novel high-throughput ELISAs to measure apoC-III on apoB ...
The CVD risk of circulating plasma apoC-III is highly dependent on its association with specific lipoproteins. For example, LDL or HDL containing.
#68.
ApoCIII enrichment in HDL impairs HDL ... - Europe PMC
Apolipoprotein CIII (apoCIII) has been reported to be tightly associated with triglyceride metabolism and the susceptibility to coronary artery disease ...
#69.
Lowering apolipoprotein CIII protects against high-fat diet ...
Increased levels of apolipoprotein CIII (apoCIII), a key regulator of lipid metabolism, result in obesity-related metabolic derangements.
#70.
Dr Rani Khatib on Twitter: "Olezarsen (APOCIII-LRx ...
Olezarsen (APOCIII-LRx) significantly ⬇️ apolipoprotein C-III, triglycerides, & atherogenic lipoproteins in patients with moderate ...
Mature ApoCIII is an acid glycoprotein containing 79 amino acid residues with a 15.5.2 Detection Methods and Reference relative molecular weight of 8.7 kDa.
#72.
AKCEA-APOCIII-LRx - European Pharmaceutical Review
News stories and articles referencing AKCEA-APOCIII-LRx on European Pharmaceutical Review.
#73.
Most recent papers with the keyword apoCIII - Read by QxMD
Apolipoprotein CIII (ApoCIII) represents a key regulator of plasma lipid metabolism and a recognized risk factor for atherosclerosis and cardiovascular ...
#74.
Transcriptional regulation of human apolipoprotein genes ...
to the apoB and apoCIII promoters, deletion of elements A1D and AIIJ from the apoA1 and apoAII promoters reduced transcription of the reporter ...
#75.
Handbook of Obesity -- Volume 1: Epidemiology, Etiology, and ...
ApoCIII Remnant Medium LDL LDL + ApoCIII ApoCIII receptor ApoCIII FIGURE 48.2 Model of lipoprotein metabolism in normal and atherogenic dyslipidemia states.
#76.
High-Density Lipoproteins: From Basic Biology to Clinical ...
of the apoCIII enhancer affected the HNF-4-mediated transactivation of the À1500 apoA-I promoter/apoCIII enhancer cluster in CaCo-2 cells to the same extent ...
#77.
B6;CBA-Tg(APOC3)3707Bres/J - The Jackson Laboratory
Common Name: human apoC-III Tg ; Strain Highlights · Transgenic. Donating Investigator(s). Dr. Jan Breslow - Rockefeller University. Originating ...
#78.
Effects of Moderate Exercise Training On ApoE And ApoCIII In ...
The study analyses the effect of moderate exercise training on this Apolipoprotein E (ApoE), Apolipoprotein CIII (ApoCIII), adiponectin, ...
#79.
Plasma fatty acid ethanolamides are associated with ...
Plasma fatty acid ethanolamides are associated with postprandial triglycerides, ApoCIII, and ApoE in humans consuming a high-fructose corn syrup-sweetened ...
#80.
ApoCIII: A multifaceted protein in cardiometabolic ... - OUCI
A regulatory element in the ApoCIII promoter that directs hepatic specific ... Foxo1 mediates insulin action on apoC-III and triglyceride metabolism, ...
#81.
ApoCIII-enriched LDL in type 2 diabetes displays altered lipid ...
Our findings indicated that intrinsic characteristics of the diabetic LDL other than apoCIII are responsible for further increased proteoglycan binding of ...
#82.
Emerging Evidence that ApoC-III Inhibitors Provide ... - CORE
Recent results also show that complete deficiency of apoC-III is not a lethal mutation and is associated with very rapid lipolysis of plasma triglyceride-rich ...
#83.
Promising APOCIII Inhibitors for SHTG and FCS Treatment
Long-recognized APOC III is a small protein that functions as a key regulator of triglyceride metabolism by inhibiting lipoprotein lipase ...
#84.
2JQ3: Structure and Dynamics of Human Apolipoprotein C-III
ApoCIII inhibits lipoprotein lipase as well as binding of lipoproteins to cell surface heparan sulfate proteoglycans and receptors ...
#85.
Endocrine and Metabolic Disorders: Clinical Lab Testing ...
Tests for ApoCII and ApoCIII may be indicated in patients with: • Diabetes mellitus (T1DM and T2DM) • Extreme hypertriglyceridemia (e.g., >1000 mg/dL or ...
#86.
Isis Reports Phase 2 Data on ISIS-APOCIII Rx Showing ...
In addition, patients treated with ISIS-APOCIIIRx experienced an up to 52 percent increase in high-density lipoprotein cholesterol (HDL-C), the 'good' ...
#87.
Ionis Pharma initiates phase 3 BALANCE study for AKCEA ...
AKCEA-APOCIII-LRx is designed using Ionis' proprietary Ligand Conjugated ... to inhibit production of apolipoprotein C-III (apoC-III), ...
#88.
Handbook of Obesity, Two-Volume Set - 第 533 頁 - Google 圖書結果
48.2.4 aPOliPOPrOtein ciii ApoCIII is a modulator of TG metabolism and increased levels are a feature of atherogenic dyslipidemia. ApoCIII is bound to apoB ...
#89.
a polipoprotein c3 (apociii) antagonists and methods of their ...
Provided herein are methods of increasing lipoprotein lipase (LPL) activity, by inhibiting apolipoprotein C3 (ApoCIII), which removes the ...
apociii 在 Jean-Claude Tardif, MD: APOCIII-Lrx and CV Risk Reduction 的推薦與評價
Lead investigator discusses a new study that assessed APOCIII -Lrx's efficacy and safety in reducing apolipoprotein C-III and triglycerides ... ... <看更多>