China Halts Work by Scientist Who Says He Edited Babies’ Genes
中國暫停賀建奎研究基因編輯嬰兒
China said on Thursday that it had suspended the work of a scientist who claims to have created the world’s first genetically edited babies, saying his conduct appeared to be unethical and in violation of Chinese law.
週四,中國表示已暫停一名聲稱創造了世界首例基因編輯嬰兒的科學家的工作,稱其行為不道德,且違反了中國法律。
The scientist, He Jiankui, announced on Monday that he had used the gene-editing technique Crispr to alter embryos, which he implanted in the womb of a woman who gave birth to twin girls this month. At an international conference on Wednesday, he asserted that he was proud of what he had done.
週一,科學家賀建奎宣佈,他利用基因編輯技術Crispr改變胚胎,並將其植入了一名女性的子宮,該名女性在本月生下一對雙胞胎女兒。在週三的一個國際會議上,他堅稱為自己所做的一切感到自豪。
Xu Nanping, China’s vice minister of science and technology, said Dr. He’s work was still being investigated. But based on news reports, he said, Dr. He appeared to have “blatantly violated China’s relevant laws and regulations” and broken “the bottom line of morality and ethics that the academic community adheres to,” the state broadcaster China Central Television reported on Thursday.
中國科技部副部長徐南平表示,對賀建奎工作的調查仍在進行中。根據官方的中央電視臺週四報導,他說,這次媒體報導的基因編輯嬰兒事件「公然違反了我國的相關法規條例」,也突破了「學術界堅守的道德倫理的底線」。
“It is shocking and unacceptable,” Mr. Xu was quoted as saying. “We are resolutely opposed to it.”
這「令人震驚不可接受」,報導引用徐南平的話說,「我們是堅決反對的。」
The suspension follows international condemnation from scientists who maintain that Dr. He’s conduct was unethical. They say there are serious unanswered questions about the safety of embryo editing and a need to make sure that such research is conducted in a transparent, monitored way so the technology is not misused.
在暫停職務之前,國際上的科學家譴責賀建奎的行為不道德。他們表示,胚胎編輯的安全性存在嚴重且尚未解決的問題,需要確保以透明、受監控的方式進行這類研究,以免這項技術遭到濫用。
Mr. Xu had said earlier that Chinese regulations issued in 2003 permitted gene-editing experiments on embryos for research purposes, but only if they remained viable for no more than 14 days.
徐南平早些時候曾表示,中國監管部門在2003年頒佈的法規允許對胚胎進行基因編輯實驗,但前提是這些胚胎的存活時間不超過14天。
On Monday, a group of 122 Chinese scientists issued a statement calling Dr. He’s actions “crazy” and his claims “a huge blow to the global reputation and development of Chinese science.”
週一,122名中國科學家發表連署聲明,稱賀建奎的行為「瘋狂」,他的言論「對於中國科學在全球的聲譽和發展都是重大的打擊」。
At the Second International Summit on Human Genome Editing in Hong Kong on Wednesday, Dr. He acknowledged that he had not made his university in China aware of the research he was doing. He said he had initially paid for the research himself, then later from his university funding.
在週三於香港召開的第二屆人類基因組編輯國際高峰會上,賀建奎承認,他沒有讓他任職的中國大學知道他正在做的這項研究。他表示,最初自己支付了這項研究的費用,後來用的是大學的經費。
Dr. He pushed back against suggestions that he had been secretive about his work, saying that he had presented preliminary aspects of it at conferences and consulted with scientists in the United States and elsewhere. He said he had submitted his research to a scientific journal for review and had not expected to be presenting it at the conference.
賀建奎反駁了有關他對自己的工作守口如瓶的說法,指出他曾在各種會議上展示過初步的研究成果,並諮詢了來自美國和其他地方的科學家。他表示,已經將研究報告提交給了一份科學雜誌進行審議,且原本沒想到會在本次大會上發表。
One of many areas of confusion about Dr. He’s research was the status of a possible pregnancy of a second woman he said he had implanted with an edited embryo. On Wednesday, under questioning from scientists after his talk, Dr. He said there had been a second implantation in an early stage.
關於賀建奎的研究,有許多令人困惑的地方,其中之一是他所說的已經植入了被編輯過的胚胎、可能懷孕的第二名女性的情況。週三,在演講結束後,賀建奎接受了科學家的提問,他表示,第二例植入還處在早期階段。
When asked by Robin Lovell-Badge, a professor of genetics and embryology at the Francis Crick Institute in London, whether by early stage Dr. He meant a “chemical pregnancy” or early miscarriage, Dr. He said “yes.”
當被倫敦Francis Crick Institute的遺傳學和胚胎學教授Robin Lovell-Badge問道,他所說的「早期階段」是指「化學妊娠」(即早期流產)嗎,賀建奎回答,「是的」。
On Thursday, however, Dr. Lovell-Badge told reporters that he could not be sure that Dr. He understood that “chemical pregnancy” referred to a pregnancy that was lost.
然而,Lovell-Badge博士在週四告訴記者,他不能確定賀建奎是否理解「化學妊娠」指的就是流產。
“He doesn’t necessarily know what he’s talking about,” Dr. Lovell-Badge said. “We don’t know. He said he confirmed that essentially they’d done the hormone test for whether or not the woman was pregnant. And the answer is yes. But it’s very early, so it could turn into a chemical pregnancy meaning there was a miscarriage. Many embryos fail to survive.”
「他不一定知道自己在說什麼,」Lovell-Badge博士說,「我們也不知道。他說他可以證實他們已經做了激素檢測,以確定這名女子是否懷孕。答案是肯定的。但現在為時尚早,所以也可能會變成化學妊娠,也就是流產。許多胚胎無法存活。」
Dr. He had been scheduled to speak again at the conference on Thursday, but his talk was canceled.
賀建奎原定於在週四的會議上再次發言,但已被取消。
Dr. Robin Lovell-Badge, who moderated the Wednesday session, said in an email that “it would have been difficult to have sufficient security” for a second talk. He said that Dr. He had decided not to attend after he was told about the security arrangements.
Lovell-Badge博士主持了週三的會議,他在一封電子郵件中說,「很難有足夠的安全措施」保障賀建奎的第二次發言。他表示,賀建奎在得知安保安排後,決定不再參加。
Dr. Lovell-Badge said Thursday that the organizers had felt it was “important to give Dr. He a platform to present what he had done.”
Lovell-Badge博士週四表示,主辦方認為,「給賀建奎一個展示他所做的事情的平臺很重要。」
“We therefore do not regret at all allowing him to present yesterday, but giving him a second opportunity today might also have been viewed as support for him,” he said. “This is another reason the committee did not want him back today.”
「因此,我們一點也不後悔允許他昨天發表演講,但今天給他第二次機會也可能被視為對他的支援,」他說,「這也是委員會不希望他今天再次現身的另一個原因。」
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อยู่กับ 'โรคซึมเศร้า' ข้างๆ กัน
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สอง-สามปีมานี้ ผมพบว่าคนรอบตัวทั้งเพื่อนพ้องน้องพี่มีอาการเบื่อๆ อยากๆ หรือที่เรียกกันว่า 'โรคซึมเศร้า' กันหลายคน ตัวผมเองก็มีบางช่วงเวลาที่เซ็งๆ เนือยๆ นอยๆ อยู่บ้างเหมือนกัน แต่เมื่อลองนั่งคุยกับคนที่มีอาการของโรคอย่างแท้จริงก็พบว่า คนที่เป็นโรคนั้นมีภาวะที่แตกต่างไป ผมเคยไม่เข้าใจคนที่เป็นโรคนี้มาก่อน ทำให้เผลอปฏิบัติตัวไปในทางที่ผิด คิดอยากช่วยแต่กลับทำให้ทุกอย่างดูแย่ลงไปอีก วันนี้อยากลองแชร์ความคิดและข้อมูลบางอย่างเผื่อจะเป็นประโยชน์ท...
Continue ReadingLive with 'depression' next to each other.
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Two-three years ago, I found that people around me, friends, brothers and sisters. I want to be bored, aka ' depression '. Many people have some times that I'm tired. Some of the same time, but when I sit and talk to someone who has a real disease, I found that people with different condition. I didn't understand. People who have this disease before. I accidentally act in the wrong way. I want to help, but I do everything. Looking worse today. I want to share some thoughts and information. In case it's beneficial with depression, including close ones. Of course I'm not a doctor. I just want to tell you and talk about some aspects. If anyone has good information or helpful ways to do it. Feel free to share. It should be beneficial to many people.
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1. Before speaking, we should listen.
People around patients with depression often judge and look at their own eyes. We always try to sedition to be strong, have goals, ask about passion, and whatever you think it will be powerful with life. Sometimes I accidentally scold. Said why he is so tired, lazy, long spine, doesn't do anything. Sometimes I encourage him to get up to do something. All of this with best wishes, but know that for patients. These things. The more it makes the situation worse because it shows the understanding of the condition he is experiencing. If someone close to be bored before he lets him do many things, we should give him a bit of how he feels about the world and our lives. To understand more
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Lol he didn't want to be
When we listen, we will understand that the condition he is very difficult because it is an insensitive feeling about everything, no negative, no negativity, nothing, no meaning, don't want to don't want to do anything, don't want to talk to anyone, which he doesn't even want to be The more pressure in the world that everyone has to work hard, the more you feel worthless. I want to get up to work, but I don't have enough strength. Besides being tired, we still have to fight the value that society around you. It's a time that is not easy. I am.
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Lol he may not be stressed by anything. Suddenly it happens.
Everyone has stress, but it's all caused by something. While this disease is different. Sometimes - one day this symptom happened yesterday, I still smile. Today we can't tell him. " Hey, keep thinking positive " or " just change the way of thinking, life changes " something like that. When it happens, it will last for weeks or months. During that time. Patients will be the one who don't want to do anything, whether it's work. Playing or even showing love with love is a great time of understanding and if he says " you don't understand me that's what he really wants to say
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4. Give him time to give us time
During that time, he will change to a different person. It may be a bad person who has been active. May not be bored of work. I may not get out of bed or insomnia, no strength. Sometimes I don't think that they don't want to live. It's a time when people. All around you should give time to not try to make him get well quickly because it's impossible. But it shouldn't be more pressure or take care of it. Because this moment, he may not have much mood to interact with anyone. Give time. Him and with us.
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Lol it's about chemicals in the brain
What we should understand is that this disease is not caused by an attitude or perspective to the world. Even when it affects the world, but the cause of the brain, there may be some chemicals in the brain that is low or some medical disorders. Still can't answer. What is the real cause of it? It may be genes or mixed environment. When we understand this, we will see that it's normal that people have some disease in some times. Comparison to cold may not be right, but think about it. Sometimes some diseases come into life. Give it time. It will slowly unfold.
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Lol call it a disease to feel normal
When this is a symptom of a disease. Instead of a disease, we should feel like it is normal for human beings. It should not feel that we should not feel bad. We have a disease or someone beside us. Just a normal thing that happens to keep us beside each other to support and understand together.
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7. Do you want to change the name of the disease?
I really want to rethink about this disease. The word ' depression ' makes us not want to tell anyone that I have this disease. In fact, we are not going to be depressed for the rest of my life or all the time. I want to call it ' disease. What are you tired? ' because it's temporarily tired. Well, people can be tired? It's only temporary. I will come back to have new power. Just ' I'm not ' not ' depressed ' Go forever. Don't panic.
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Haha. Invite him to go to the doctor.
Many patients don't know that there is a disease in the world. Some people may not admit that they are in America. There is an average that each patient takes more than ten years to ask for advice from the doctor. Even going to the doctor can help you feel better. Sitting and talking. Paying medicine to balance brain chemistry, including doctor's advice is beneficial to patients. If someone close to have some symptoms, you should recommend him to go to the doctor. It's like we have a sore throat and fever. We need to find a doctor. Isn't we find a doctor? Doctor cures this disease. It's not a shocking thing. As I said it's normal. People can have a disease.
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Haha. You are not weak. You can tell each other.
Whether we have this disease or close ones, one thing we should understand is that we are not weaker than others. It's one condition that something in the brain is unbalanced. In that condition may have an idea to compare ourselves to others, such as opening Facebook. I feel like everyone is happier than me (a little less on Facebook) or compare to myself when I'm brighter, but it's similar to when we ankle. We can't go back to being the same right away even if I speed up the day. No matter how much you speed up, open-minded talk can heal the feeling, including telling the thoughts of suicide can help reduce the risk of suicide too. The close ones should open your mind and listen and some people should open your mind to tell the feeling. People we can trust. Tell the world that I have this disease. People around you will understand that in the midst of society that don't understand. Patients will make patients feel worried. We don't dare to tell anyone. So we need more understanding in society for the story that are walking around. Inside will be told more comfortably.
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Lol let's exercise
I found that many brothers and sisters who have a disease. Better, brighter, more power from exercise. Even if you try and do it continuously, you will slowly feel better. Exercise may cause some chemicals in the brain to add good feelings for us. Some people say that we have lived in the field before. Before we have to run for food. Now we have to sit in a narrow air conditioning room all day. It makes it unnatural. So we should find When you return to our natural activity. Exercise is a magic pill. It helps both chemicals. It helps to help healthy. If there are people close to you, try to invite them to exercise together. But don't have to much pressure. Take it slow.
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All that I think spreading knowledge of understanding is very important. Both close level is to interaction with patients in the house. If we understand, we will treat each other better and at the level of Society is wide. If society understands, patients will dare to speak. Dare to tell others stories and feelings.
It's not strange that we have some moments to cross over. Whether at the level of family or society. I think we need understanding of each other to be beside each other to cross that time. There is still a bright tomorrow waiting. I'm still here.
If it's not too disturbing, I want to share this information to help create more understanding of this disease. If anyone has any information, please comment and tell me. It should be beneficial to everyone.
Thank youTranslated
genes meaning 在 Corey The Man Yoga Facebook 的精選貼文
瑜珈改變基因表達
Yoga Changes the Gene Expression (English Below)
許多研究發現瑜珈對於身體及心理的幫助是有益的,但實際生化機制上是一個謎。挪威的奧斯陸大學最新研究顯示瑜珈練習對於基因表達(特別是免疫細胞)有快速及衝擊性的影響;這些數據顯示瑜珈練習的療癒效應會立即且全面性的影響身體的分子結構。
首先,瑜珈練習並不會改變你的基因,也就是下犬式做久了你不會變成一條狗,但瑜珈練習會影響你的基因表達(genetic expression)。何謂基因表達? DNA像是一部電影的膠卷,RNA像是電影的投射機,那麼製造出來的蛋白質變像是一部聲色俱佳的電影,這部電影就是基因的表達。換句話說,基因會像燈一樣被打開和關閉。
瑜珈的練習會造成一些基因的啟動,特別是免疫系統。
奧斯陸大學的研究了十名測試者,前兩天他們參與了兩小時的瑜珈練習,練習前後的抽血報告顯示,有111種的基因表達因此而改變 (Peripheral blood mononuclear cell 外週血單核細胞)。幾天後,他們讓這些測試者連續兩天在森林散步二小時,聽音樂放鬆,測試前後的抽血報告發現只有38樣基因表達被改變*。此項研究顯示瑜 珈是有效及快速地在基因層面提供對健康有益的因子。研究者說: 比起一般傳統的放鬆方式,瑜珈的練習在分子結構上影響較為廣泛。
Researchers first reported five years ago that practices such as yoga which elicit the “relaxation response” may have a long-term effect on gene expression. That’s the scientific term for whether a specific gene is “turned on,” meaning its protein or RNA product is being made. This latest study confirms those findings, links them to the body’s immune system, and suggests this effect may be instantaneous.
First of all, yoga doesn’t change your Gene (you won’t turn into a dog doing downward facing dog) but it will affect your gene expression. What is Gene expression ? DNA is like a film of a movie, RNA is like the movie projector and the protein it created is like a movie. The movie is the expression of the gene. In other words, the gene can be turned on and off like a light switch.
The University of Oslo experiment featured 10 participants who attended a week-long yoga retreat in Germany. For the first two days, participants spent two hours practicing a comprehensive yoga program including yogic postures (asanas), yogic breathing exercises (in particular Sudarshan Kriya), and meditation. For the next two days, they spent that same time period going on an hour-long nature walk and then listening to either jazz or classical music.
Immediately before and after each of the four sessions, the researchers drew blood from each participant. They then isolated and analyzed peripheral blood mononuclear cells, which play a key role in the body’s immune system. The researchers found that the nature walk and music-driven relaxation changed the expression of 38 genes in these circulating immune cells. In comparison, the yoga produced changes in 111. *
The two regimens, to some degree, affect similar biological processes,” the researchers write. That said, they note that yoga's impact was far more widespread, which indicates the practice “may have additional effects over exercise plus simple relaxation in inducing health benefits through differential changes at the molecular level.”
* http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0061910
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