Search
Search
#1. Phase I/II study of tirabrutinib, a second-generation Bruton's ...
Background: The safety, tolerability, efficacy, and pharmacokinetics of tirabrutinib, a second-generation, highly selective oral Bruton's ...
Tirabrutinib (brand name Velexbru) is a drug used for the treatment of autoimmune disorders and hematological malignancies.
#3. Taiwan Food and Drug Administration Assessment Report
Velexbru® (Tirabrutinib HCl) is a drug for the treatment of relapsed or refractory primary central nervous system lymphoma. Tirabrutinib is a ...
#4. Tirabrutinib - an overview | ScienceDirect Topics
Tirabrutinib (ONO/GS-4059) is a highly selective, efficient and oral second-generation BTK inhibitor developed by the ONO company of Japan 10. Tirabrutinib ...
#5. Real-World Evidence for the Safety and Effectiveness of ...
Tirabrutinib is a second-generation inhibitor of Bruton's tyrosine kinase with higher kinase selectivity than ibrutinib (Banerji et al., 2020), ...
#6. FDA Grants ODD to Tirabrutinib for Primary Central Nervous ...
Tirabrutinib is a highly potent selective BTK inhibitor which signals through the B-cell receptor (BCR) to regulate cellular proliferation and ...
#7. Long-term safety profile of tirabrutinib: final results of a ...
Tirabrutinib is a Bruton's tyrosine kinase inhibitor for treating B-cell malignancies. We report the final results of a Phase I study of ...
#8. Definition of tirabrutinib - NCI Drug Dictionary
An orally available formulation containing an inhibitor of Bruton agammaglobulinemia tyrosine kinase (BTK), with potential antineoplastic activity.
#9. Study of Tirabrutinib (ONO-4059) in ... - ClinicalTrials.gov
This study will evaluate the efficacy, safety, and pharmacokinetics of tirabrutinib monotherapy in patients with relapsed or refractory PCNSL (Part A), ...
#10. Tirabrutinib: First Approval. - Abstract - Europe PMC
Tirabrutinib (Velexbru ® ) is an orally administered, small molecule, Bruton's tyrosine kinase (BTK) inhibitor being developed by Ono Pharmaceutical and its ...
#11. Tirabrutinib (ONO-4059) hydrochloride is a potent and ...
Tirabrutinib (ONO-4059) hydrochloride is a potent and selective BTK (Bruton's Tyrosine Kinase) inhibitor (IC₅₀ = 2.2 nm). Tirabrutinib binds to BTK within B ...
#12. FDA Grants Orphan Drug Designation to Tirabrutinib in ...
Tirabrutinib is a highly potent, selective Bruton tyrosine kinase (BTK) inhibitor regulating cellular proliferation and activation through the B ...
#13. Tirabrutinib: First Approval - ResearchGate
In March 2020, oral tirabrutinib was approved in Japan for the treatment of recurrent or refractory primary central nervous system lymphoma. Tirabrutinib is ...
#14. TIRABRUTINIB - Inxight Drugs
Tirabrutinib (also known as ONO-4059 or GS-4059), a second-generation, enhanced-selectivity Bruton's tyrosine kinase inhibitor that demonstrated antitumor ...
#15. 台首個復發/難治性中樞神經系統淋巴瘤BTK抑制劑獲批有望成 ...
昨(21)日,小野藥品工業(Ono Pharmaceutical)宣布,其台灣子公司台灣小野藥品工業的Velexbru®(tirabrutinib hydrochloride)片劑80 mg獲得臺灣食藥 ...
#16. Dr Asai on Final Results From a Phase 1/2 Trial of Tirabrutinib ...
Katsunori Asai, MD, PhD, Department of Neurosurgery, Osaka International Cancer Institute, Osaka, Japan, discusses the use of tirabrutinib ...
#17. KEGG DRUG: Tirabrutinib hydrochloride
D11070 Tirabrutinib hydrochloride (JAN/USAN) Drug groups [BR:br08330] Antineoplastic DG01918 Tyrosine kinase inhibitor. DG02022 BTK inhibitor
#18. tirabrutinib | Ligand page
Comment: Tirabrutinib (ONO-4059) is a potent, reversible Bruton's tyrosine kinase (BTK) inhibitor. It is one of the compounds claimed in patent ...
#19. Tirabrutinib (ONO-4059) | BTK Inhibitor - MedChemExpress
Tirabrutinib (ONO-4059) is an orally active Bruton's Tyrosine Kinase (BTK) inhibitor (can cross the blood-brain barrier (BBB)), with an IC50 of 6.8 nM.
#20. Tirabrutinib Hydrochloride;替拉鲁替尼盐酸盐 - 索莱宝
当前位置: 首页 > 小分子化合物 > 抑制剂&拮抗剂&激动剂 > Protein Tyrosine Kinase/RTK 蛋白酪氨酸激酶 > Btk/布鲁顿酪氨酸激酶 > Tirabrutinib Hydrochloride;替 ...
#21. Phase 2 Clinical Study Initiated for Velexbru (tirabrutinib), a ...
Velexbru, discovered and developed by ONO, is a highly selective, oral BTK inhibitor and has been developed for the treatment in patients with B ...
#22. tirabrutinib(ONO-4059) hydrochloride | 99.77%(HPLC)
Tirabrutinib Hydrochloride (ONO-4059, GS-4059) is a highly potent and selective BTK inhibitor with an IC50 of 2.2 nM. Quality confirmed by NMR & HPLC.
#23. ONO PHARMA USA's Tirabrutinib Receives ... - BioSpace
ONO PHARMA USA's Tirabrutinib Receives Orphan Drug Designation from the FDA for the Treatment of Primary Central Nervous System Lymphoma ...
#24. Tirabrutinib | BTK - 陶术生物
Tirabrutinib (ONO-4059) 是一种口服有效的高选择性Bruton's Tyrosine Kinase (BTK) 抑制剂(能透过血脑屏障),其IC50 值为6.8 nM。Tirabrutinib 不可逆共价结合BTK 并 ...
#25. Investigation of the anti-tumor mechanism of tirabrutinib, a ...
Tirabrutinib is a highly selective Bruton's tyrosine kinase (BTK) inhibitor used to treat hematological malignancies. We analyzed the anti-tumor mechanism ...
#26. Tirabrutinib hydrochloride | 1439901-97-9 | B2556 - BioVision
Tirabrutinib (ONO-4059) hydrochloride is a potent and selective BTK (Bruton's Tyrosine Kinase) inhibitor (IC₅₀ = 2.2 nm). Tirabrutinib binds to BTK within B ...
#27. ML-9 TREATMENT OUTCOMES OF TIRABRUTINIB FOR ...
Tirabrutinib, Bruton's tyrosine kinase inhibitor was introduced for treatment of recurrent and refractory PCNSL in Japan. However, case series ...
#28. 鹽酸替拉魯替尼Tirabrutinib hydrochloride (Velexbru) - DrugsHK
劑量: 80 mg 商品名稱: Velexbru 生產企業: Ono Pharmaceutical Co., Ltd. 包裝規格: 20粒適應症: 淋巴瘤.
#29. Tirabrutinib | ≥99%(HPLC) | BTK inhibitor | AdooQ®
Tirabrutinib (ONO-4059) is a highly selective, orally bioavailable BTK inhibitor with an IC50 of 2.2 nM.
#30. Two‐year outcomes of tirabrutinib monotherapy in ...
Tirabrutinib is a second-generation, irreversible BTK inhibitor with high selectivity and fewer off-target effects. A phase II study (ONO-4059- ...
#31. Tirabrutinib (hydrochloride) - tcsc5637 - Taiclone
Tirabrutinib (ONO-4059) hydrochloride is a selective and novel inhibitor of BTK with IC50 2.2 nm, Tirabrutinib binds to BTK within B cells, ...
#32. Tirabrutinib hydrochloride by Ono Pharmaceutical for Primary ...
Tirabrutinib hydrochlorideis under clinical development by Ono Pharmaceutical and currently in Phase II for Primary CNS Lymphoma.
#33. Tirabrutinib hydrochloride - BioVision
Tirabrutinib (ONO-4059) hydrochloride is a potent and selective BTK (Bruton's Tyrosine Kinase) inhibitor (IC₅₀ = 2.2 nm). Tirabrutinib binds to BTK within B ...
#34. Tirabrutinib - Orphanet
Tirabrutinib. INN (International Nonproprietary Name) : tirabrutinib; Code name : GS-4059; Chemical name or description : 6-Amino ...
#35. HY-15771-10mg | Tirabrutinib [1351636-18-4] Clinisciences
Tirabrutinib (ONO-4059) is an orally active Bruton's Tyrosine Kinase (BTK) inhibitor (can cross the blood-brain barrier (BBB)), with an IC50 of 6.8 nM.
#36. Study of Tirabrutinib (ONO-4059) in ... - Stanford Health Care
Study of Tirabrutinib (ONO-4059) in Patients With Primary Central Nervous System Lymphoma (PROSPECT Study). Trial ID or NCT#. NCT04947319. Status. recruiting ...
#37. ONO PHARMA USA's Tirabrutinib Receives ... - PR Newswire
Tirabrutinib, discovered and developed by Ono Pharmaceutical Co., Ltd., is a highly potent selective BTK inhibitor. Signaling through the B-cell ...
#38. tirabrutinib(ONO-4059) hydrochloride | BTK 抑制剂| 现货供应
Tirabrutinib Hydrochloride (ONO-4059, GS-4059) 是一种高度有效的、选择性的BTK抑制剂,IC50为2.2 nM。 靶点. BTK. 2.2 nM. 体外研究. 相较于Lck ...
#39. Experience With Tirabrutinib in the Treatment of Primary ...
Tirabrutinib is a second-generation Bruton's tyrosine kinase (BTK) inhibitor that can be administered orally (14). In the present study, the outcomes of ...
#40. Tirabrutinib hydrochloride | BTK - TargetMol
Tirabrutinib hydrochloride is a selective and novelBTK with IC50 2.2 nm inhibitor. All products from TargetMol are for Research Use Only. Not for Human or ...
#41. ONO-4059 (GS-4059, ONO-WG-307, Tirabrutinib, CAS Number
GS-4059; ONO-WG-307; Tirabrutinib. Molecular Formula. C25H22N6O3. Formula Weight. 454.5. Purity. ≥98%. Formulation(Request formulation change).
#42. Medline ® Abstract for Reference 74 of 'Primary central ...
Tirabrutinib (Velexbru®) is an orally administered, small molecule, Bruton's tyrosine kinase (BTK) inhibitor being developed by Ono Pharmaceutical and its ...
#43. Phase 1b study of tirabrutinib in combination with idelalisib or ...
Tirabrutinib (TIRA, formerly ONO/GS-4059) is a selective, irreversible, and small-molecule BTK inhibitor [6, 7].
#44. Tirabrutinib: Uses, Interactions, Mechanism of Action - DrugBank
Tirabrutinib is under investigation in clinical trial NCT02626026 (Safety and Pharmacokinetics of GS-4059 in Healthy Volunteers and Subjects ...
#45. Report on the Deliberation Results - PMDA
As of November 2019, tirabrutinib has not been approved in any country or region. In Japan, a Phase I study (Study ONO-4059-01 [Study 01]) ...
#46. Phase Ib Study of Tirabrutinib in Combination with Idelalisib or ...
Tirabrutinib (formerly ONO/GS-4059) is a selective, irreversible, second-generation, small-molecule BTK inhibitor (5, 10). Tirabrutinib irreversibly binds to ...
#47. tirabrutinib – Hematology & Oncology
Tags: tirabrutinib · Bruton Tyrosine Kinase Inhibitors for the Treatment of Mantle Cell Lymphoma: Review of Current Evidence and Future Directions ...
#48. Tirabrutinib - BLDpharm
Tirabrutinib | BLDpharm.com. ... Products >Pharmaceutical Intermediates >Antineoplastics >Tirabrutinib. Products(0) Items 1-30 of 0.
#49. A Phase II Study of Tirabrutinib to Treat Primary Central ...
Tirabrutinib blocks a protein called BTK, which some cancer cells need to grow and survive. Blocking BTK may slow or stop PCNSL growth. It is a tablet that is ...
#50. The safety and efficacy of tirabrutinib and entospletinib with or ...
In this video, Barbara Eichhorst, MD, University Hospital Cologne, Cologne, Germany, shares some results from a Phase II trial investigating ...
#51. Tirabrutinib - VJHemOnc
Tirabrutinib and entospletinib or idelalisib with or without obinutuzumab in R/R CLL. Barbara Eichhorst • 7 Oct 2022.
#52. Tirabrutinib free base | ONO-4059 free base | CAS#1439901 ...
Tirabrutinib, also known as ONO-4059 is a potent and orally active Bruton agammaglobulinemia tyrosine kinase (BTK) in hibitor. Upon administration, ONO-4059 ...
#53. Tirabrutinib (ONO-4059) | Cas# 1351636-18-4 - GlpBio
Tirabrutinib (ONO-4059) (ONO-4059) is an orally active Bruton's Tyrosine Kinase (BTK) inhibitor (can cross the blood-brain barrier (BBB)), with an IC50 of ...
#54. An Open-label Phase II Study to Investigate the Efficacy ...
This study will evaluate the efficacy, safety, and pharmacokinetics of tirabrutinib monotherapy in patients with relapsed or refractory ...
#55. Histological verification of the treatment effect of tirabrutinib for ...
Tirabrutinib (ONO/GS-4059; Ono Pharmaceutical) is a newly developed drug that selectively and irreversibly inhibits Bruton's tyrosine kinase ...
#56. A multicenter, open-label, uncontrolled, single-arm phase 2 ...
From the perspective of convenience, tirabrutinib is an oral agent that is taken once daily. Therefore, it would not negatively impact daily ...
#57. Tirabrutinib in B-cell lymphoma: a phase 1 study looking at a ...
The aim of this trial is to find out more about using a new treatment called tirabrutinib to treat B-cell lymphomas. The trial is for people whose lymphoma ...
#58. Follow-Up Data on Tirabrutinib in Treatment-Naïve and ...
Second-generation oral Bruton tyrosine kinase (BTK) inhibitor tirabrutinib demonstrated sustained efficacy in treatment-naïve (TN) and ...
#59. s Tyrosine Kinase (Btk) Inhibitor Tirabrutini - Prime Scholars
Abstract. Bruton's Tyrosine Kinase (Btk) Inhibitor Tirabrutinib Prevents the Development of Murine Lupus. Yuko Ariza, Masayuki Murata, Yoshiko Ueda and ...
#60. ONO PHARMA USA's Tirabrutinib Receives ... - Yahoo Finance
ONO PHARMA USA, INC., announced that its candidate, tirabrutinib (ONO-4059), a Bruton's tyrosine kinase inhibitor, was granted Orphan Drug ...
#61. Homogeneous BTK Occupancy Assay for ... - SAGE Journals
Tirabrutinib (GS-4059/ONO-4059, Gilead Sciences, Inc., Foster City, CA) is a second-generation, potent, selective, irreversible BTK inhibitor in clinical ...
#62. TIRABRUTINIB
物质名称, TIRABRUTINIB. 异名/同义词, 6-AMINO-9-((3R)-1-(2-BUTYNOYL)-3-PYRROLIDINYL)-7-(4-PHENOXYPHENYL)-7,9-DIHYDRO-8H-PURIN-8-ONE
#63. ONO PHARMA's Tirabrutinib Receives FDA Orphan Drug ...
ONO PHARMA USA announced that its candidate, tirabrutinib (ONO-4059), a Bruton's tyrosine kinase inhibitor, was granted Orphan Drug ...
#64. GS-4059 (Tirabrutinib) - Chemgood
GS-4059 (Tirabrutinib) is a potent and orally bioavailable BTK (Bruton's tyrosine kinase) inhibitor.
#65. Efficacy and Safety of the Combination of Tirabrutinib and E...
Tirabrutinib, a second-generation BTK inhibitor, binds irreversibly and covalently to BTK. In a phase 1 trial, tirabrutinib was well tolerated in relapsed/ ...
#66. Tirabrutinib CAS No. : 1351636-18-4 - Chemscene
ChemScene Provide Tirabrutinib(CAS 1351636-18-4)In-stock or Backordered impurities,Bulk custom synthesis,Formular C25H22N6O3,MW 454.48 bulk manufacturing, ...
#67. Phase I/II study of tirabrutinib, a second ... - Tohoku University
Phase I/II study of tirabrutinib, a second-generation Bruton's tyrosine kinase inhibitor, in relapsed/refractory primary central nervous system ...
#68. 化合物TIRABRUTINIB_化工百科 - ChemBK
中文名:替拉鲁替尼,英文名:Btk Kinase inhibitor,CAS:1351636-18-4,用途一种有效的口服活性的BTK(布鲁顿酪氨酸激酶)抑制剂.购买化合物TIRABRUTINIB.
#69. A Case of Bing-Neel Syndrome Successfully Treated ... - J-Stage
Tirabrutinib may have utility as an effective treatment for BNS. 引用文献 (15). 1. Swerdlow S, Campo E, Harris N, et ...
#70. Efficacy and Safety of the Combination of Tirabrutinib and ...
Tirabrutinib and Entospletinib With or Without. Obinutuzumab in Relapsed Chronic Lymphocytic. Leukemia. Nadine Kutsch1, Christian Pallasch2, Eugen Tausch3, ...
#71. Phase I/II study of tirabrutinib, a second-generation Bruton's ...
Phase I/II study of tirabrutinib, a second-generation Bruton's tyrosine kinase inhibitor, in relapsed/refractory primary central nervous system lymphoma · 抄録.
#72. Medchemexpress LLC HY-15771A 5mg ... - Fisher Scientific
Shop Medchemexpress LLC HY-15771A 5mg Medchemexpress, Tirabrutinib (hydrochloride) CAS:1439901-97-9 Purity:>98% at Fishersci.com.
#73. tirabrutinib hydrochloride - Drug Central
Tirabrutinib is a potent and selective Bruton's tyrosine kinase (BTK) inhibitor that irreversibly and covalently binds to BTK Cys-481 in B cells and ...
#74. Study of Tirabrutinib (ONO-4059) in Patients With Primary ...
Study of Tirabrutinib (ONO-4059) in Patients With Primary Central Nervous System Lymphoma (PROSPECT Study).
#75. Brutons Tyrosine Kinase (Btk) Inhibitor Tirabrutinib ... - iMedPub
Brutons Tyrosine Kinase (Btk) Inhibitor Tirabrutinib Suppresses Osteoclastogenesis and Inflammation in a Mouse CollagenInduced Arthritis Model, Yuko Ariza,
#76. Tirabrutinib Well-Tolerated as Combo or Monotherapy for ...
Therapy with tirabrutinib alone or plus idelalisib or entospletinib was well-tolerated in patients with CLL in an open-label study. Blood Cancer News.
#77. Clinical Trial Information - Orlando Health
To evaluate the efficacy of Tirabrutinib monotherapy in patients with R/R PCNSL.
#78. Tirabrutinib in Patients With Primary Central Nervous System ...
Primary central nervous system lymphoma is an aggressive cancer that forms in the lymph tissue of the brain and/or the spinal cord. Tirabrutinib acts by ...
#79. Phase 1b Study of Tirabrutinib in Combination With Idelalisib or
Tirabrutinib (TIRA, formerly ONO/GS-4059) is a selective, irreversible, small-molecule BTK. 40 inhibitor.6, 7 TIRA has greater target selectivity compared ...
#80. Ann Reed Vogel on LinkedIn: FDA Grants ODD to Tirabrutinib ...
My Dad's PCNS Lymphoma diagnosis in 2008 was almost certainly a death sentence. Instead, a clinical trial through Northwestern and SKCC saved his life and ...
#81. Responses to the Selective Bruton's Tyrosine ... - Sigma-Aldrich
Responses to the Selective Bruton's Tyrosine Kinase (BTK) Inhibitor Tirabrutinib (ONO/GS-4059) in Diffuse Large B-cell Lymphoma Cell Lines.
#82. Responses to the Selective Bruton's Tyrosine Kinase (BTK ...
Tirabrutinib is an irreversible second-generation BTK inhibitor with excellent efficacy and tolerability in R/R B-cell malignancies. Tirabrutinib forms a ...
#83. Histological verification of the treatment effect of ... - ProQuest
Tirabrutinib (ONO/GS-4059; Ono Pharmaceutical) is a newly developed drug that selectively and irreversibly inhibits Bruton's tyrosine kinase (BTK) and has ...
#84. tirabrutinib | C25H22N6O3 - ChemSpider
Structure, properties, spectra, suppliers and links for: tirabrutinib, 1351636-25-3.
#85. Study of Tirabrutinib (ONO-4059) in Patients With Primary ...
Summary. This study will evaluate the efficacy, safety, and pharmacokinetics of tirabrutinib monotherapy in patients with relapsed or refractory PCNSL (Part A), ...
#86. tirabrutinib [Neurosurgery Wiki]
Tirabrutinib. Tirabrutinib (brand name Velexbru) is a drug used for the treatment of autoimmune diseases and hematological malignancies.
#87. Tirabrutinib |CAS:1351636-18-4 Probechem Biochemicals
Tirabrutinib |ONO4059;ONO-4059;GS4059;GS 4059;GS-4059 |1351636-18-4 |A potent, selective, third-generation irreversible inhibitor of mutant EGFR with IC50s ...
#88. Ono Pharma seeks Japanese approval for tirabrutinib
ONO Submits an Application for Manufacturing and Marketing Approval in Japan for Tirabrutinib Hydrochloride (ONO-4059), a BTK Inhibitor, ...
#89. Tirabrutinib: First Approval - Adis Journals
Tirabrutinib (Velexbru ® ) is an orally administered, small molecule, Bruton's tyrosine kinase (BTK) inhibitor being developed by Ono ...
#90. Tirabrutinib hydrochloride TM-T12311 | CymitQuimica
Tirabrutinib hydrochloride is a selective and novelBTK with IC50 2.2 nm inhibitor. Long term storage: Notes: Chemical properties. Molecular weight: 490.94.
#91. Tirabrutinib Hydrochloride in Primary CNS Lymphoma ...
Tirabrutinib hydrochloride (Velexbru) is a antineoplastic agent. It is formulated as film coated tablet for oral route of administration.
#92. Homogeneous BTK Occupancy Assay for Pharmacodynamic ...
An accurate pharmacodynamic assay to assess tirabrutinib target coverage in phase 1/2 clinical studies will inform dose and schedule selection ...
#93. Study of Tirabrutinib (ONO-4059) in Patients With Primary ...
Study of Tirabrutinib (ONO-4059) in Patients With Primary Central Nervous System Lymphoma (PROSPECT Study) · Join a Clinical Trial · Contact Us.
#94. Japan Tirabrutinib Approval Breaks New BTK Ground ... - Scrip
Japan has granted a marketing authorization for Ono Pharmaceutical Co. Ltd.'s Velexbru (tirabrutinib HCl) 80mg tablets, making it the first ...
#95. Buy Velexbru (tirabrutinib hydrochloride) Online • Price & Costs
Velexbru (tirabrutinib hydrochloride) is a medication used for the treatment of recurrent or refractory primary central nervous system lymphoma.
#96. A multicenter, open-label, phase II study of tirabrutinib (ONO
Tirabrutinib is a second-generation Bruton's tyrosine kinase inhibitor with greater se- lectivity than ibrutinib.
#97. 罕见淋巴瘤新药!BTK抑制剂tirabrutinib申请上市,治疗原发性 ...
2019年09月03日讯/生物谷BIOON/ --小野制药(Ono Pharmaceutical)近日宣布,已在日本提交BTK抑制剂tirabrutinib hydrochloride(ONO-4059 ...
#98. Tirabrutinib - New Drug Approvals
Tirabrutinib (Velexbru ® ) is an orally administered, small molecule, Bruton's tyrosine kinase (BTK) inhibitor being developed by Ono ...
#99. Tirabrutinib Shows Promise in Waldenström Macroglobulinemia
The second-generation Bruton tyrosine kinase inhibitor tirabrutinib (ONO/GS-4059) showed promising efficacy in patients with treatment-naive ...
tirabrutinib 在 The safety and efficacy of tirabrutinib and entospletinib with or ... 的推薦與評價
In this video, Barbara Eichhorst, MD, University Hospital Cologne, Cologne, Germany, shares some results from a Phase II trial investigating ... ... <看更多>