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#1. ApoC-III: a potent modulator of hypertriglyceridemia and ...
ApoC-III is an important emerging target linking hypertriglyceridemia with cardiovascular disease (CVD). ApoC-III is a potent modulator of many established CVD ...
#2. Apolipoprotein C-III and cardiovascular diseases
It is defined as an immunoinflammatory fibroproliferative disease, in which fatty deposits called atheromatous plaque develops, over many ...
#3. The Roles of ApoC-III on the Metabolism of Triglyceride ...
Figure 1. ApoC-III is an important mediator of an atherogenic dyslipidaemia and increased CVD risk. The hepatic APOC3 expression is induced by ...
#4. APOC3 genetic variation, serum triglycerides, and risk of ...
Hypertriglyceridemia (HTG) is a common disorder of blood lipids associated with elevated blood triglyceride (TG) concentration. · The APOC3 gene ...
#5. Broadening the Scope of Dyslipidemia Therapy by ...
APOC3 (apolipoprotein C3) is an inhibitor of LPL (lipoprotein lipase) and hepatic uptake of TGRL. ANGPTL (angiopoietin-like protein) 3 is an ...
#6. APOC3 Loss-of-Function Mutations, Remnant Cholesterol ...
Loss-of-function mutations in APOC3 associate with low remnant cholesterol levels and low risk of ischemic vascular disease (IVD).
#7. APOC-III: a Gatekeeper in Controlling Triglyceride ...
ApoC-III is associated to atherosclerosis and coronary heart disease (CHD) due to its proatherogenic properties, the inhibition of the ...
#8. Loss-of-Function Mutations in APOC3, Triglycerides, and ...
Background Plasma triglyceride levels are heritable and are correlated with the risk of coronary heart disease.
#9. Is APOC3 the driver of cardiovascular disease in people ...
It is possible that APOC3 is acting as a backseat passenger carried by TRLs and RLPs, and, as such, is a marker of an atherogenic dyslipidemia ...
Complete information for APOC3 gene (Protein Coding), Apolipoprotein C3, including: function, proteins, disorders, pathways, orthologs, and expression.
#11. APOC3 Protein Is Not a Predisposing Factor for Fat- ...
Nonalcoholic fatty liver disease (NAFLD), characterized by excessive fat accumulation in liver, is prevalent in obesity. Genetic factors that link obesity ...
#12. Entry - *107720 - APOLIPOPROTEIN C-III; APOC3
NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced ...
#13. An APOC3 3′UTR variant associated with plasma ...
Elevated APOC3 levels are an independent risk factor for cardiovascular disease, especially when APOC3 is present on apolipoprotein B–containing ...
#14. Loss-of-Function Mutations in APOC3 and Risk of Ischemic ...
They first tested whether low levels of nonfasting triglycerides were associated with reduced risks of ischemic vascular disease and ischemic heart disease.
#15. APOC3 protein expression summary
Cancer-related genes. Candidate cardiovascular disease genes. Disease related genes. FDA approved drug targets. Human disease related genes
#16. APOC3 - apolipoprotein C-III
Disease relevance of APOC3. However, when treated with ritonavir, individuals with unfavorable genotypes of APOC3 and [corrected] APOE were at risk of ...
#17. Apolipoprotein C-III reduction in subjects with moderate ...
et al. Targeting APOC3 in the familial chylomicronemia syndrome . N Engl J Med. 2014. ;. 371. : 2200. –. 2206.
#18. APOC3 - DNAlysis
Delayed clearance of triglyceride-rich lipoproteins results in hypertriglyceridemia, a disorder that is a strong contributing factor for ...
#19. Methods for the treatment of apoc3-related diseases and ...
Described are methods for treating diseases and disorders that can be mediated in part by a reduction in APOC3 gene expression in a human subject in need of ...
#20. APOC3 Gene
disease perturbations changing expression of APOC3 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. GEO Signatures of ...
#21. APOC3 - Apolipoprotein C-III - Homo sapiens (Human)
A condition characterized by high levels of high density lipoprotein (HDL) and increased HDL cholesterol levels. See also. MIM:614028. Natural variants in HALP2 ...
#22. APOC3 may not be a predictor of risk of ischemic...
The genetic background of ischemic vascular disease is actively being explored. Several studies have shown that inhibition of APOC3 significantly reduces plasma ...
#23. APOC3 polymorphisms and non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) is the histological expression of different assaults on the liver, including lipid, ...
#24. Loss-of-Function Mutations in APOC3, Triglycerides, and ...
Request PDF | Loss-of-Function Mutations in APOC3, Triglycerides, and Coronary Disease | Background: Plasma triglyceride levels are ...
#25. APOC3 and PNPLA3 in non‐alcoholic fatty liver disease: ...
... syndrome and coronary artery disease. More recently, these variants ... The carriers of APOC3 variants also had 30% higher fasting plasma APOC3 ...
#26. Apoc3 Mouse Gene Details | apolipoprotein C-III
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes. Human diseases associated with Apoc3 (2 diseases); Human ...
#27. APOC3 genetic variation, serum triglycerides, and risk of ...
Background: Hypertriglyceridemia has emerged as a critical coronary artery disease (CAD) risk factor. Rare loss-of- function (LoF) variants in ...
#28. Apoc3 (apolipoprotein C3) - Rat Genome Database
Human ortholog(s) of this gene implicated in several diseases, including apolipoprotein C-III deficiency; chronic kidney disease; familial hyperlipidemia ( ...
#29. Common APOC3 variants are associated with circulating ...
We aimed to analyze the impact of common APOC3 variants on key parameters of lipid metabolism and coronary artery disease in the largest sample ...
#30. APOC3 Interference for Familial Chylomicronaemia ...
Patients with familial chylomicronaemia syndrome (FCS) have severe hypertriglyceridaemia due to genetically absent lipolytic capacity. They have ...
#31. Human Gene APOC3 (ENST00000227667.8) from ...
HALP2 is a condition characterized by high levels of high density lipoprotein (HDL) and increased HDL cholesterol levels. SIMILARITY: Belongs to the ...
#32. ApolipoproteinC3 Gene Variants in Nonalcoholic Fatty ...
in their study among Southern European patients found no significant association between APOC3 polymorphisms and fatty liver disease, lipids and insulin- ...
#33. APOC3 rs2070667 Associates with Serum Triglyceride ...
Nonalcoholic fatty liver disease (NAFLD) reflects an important pathological syndrome demonstrating hepatocyte steatosis, ballooning, and lobular ...
#34. The APOC3 gene and its putative association with human ...
Therefore, APOC3 may impact on some age-related diseases, though its exact role in human ageing remains to be determined. Cytogenetic information.
#35. Apolipoprotein C3 genetic polymorphisms are associated with ...
... APOC3 gene polymorphisms among coronary artery disease cases and ... Table 4 Lipid profiles of coronary artery disease cases and controls according to APOC3 3238 ...
#36. Loss-of-Function Mutations in APOC3, Triglycerides, and ...
Plasma triglyceride levels are heritable and are correlated with the risk of coro- nary heart disease. Sequencing of the protein-coding regions ...
#37. ESC 2020: APOC-III Reduction in Cardiovascular Disease
... disease. The administration of APOCIII -LRX in patients with hypertriglyceridemia and high CV risk was associated with inhibition of ApoC-III ...
#38. Role of Apolipoprotein C3 in Lipid Metabolism
... disease. The relationship between these two entities and their place in ... ApoC3-HDL prevents excessive amounts of apoC3 presenting on VLDL ...
#39. Loss-of-Function Mutations in APOC3 and Risk of Ischemic ...
The risk of ischemic vascular disease was reduced by 41% among carriers of these mutations. Low-density lipoprotein (LDL) cholesterol is the principal target of ...
#40. Associations of HDL Subspecies Defined by ApoC3 with ...
Non-alcoholic fatty liver disease (NAFLD) is characterized by excessive hepatic fat accumulation in the absence of heavy alcohol intake. NAFLD ...
#41. New APOC3 loss-of-function data support apoCIII as a ...
... APOC3 gene, indicate the potential benefits of apoCIII lowering for cardiovascular disease (CVD) prevention. Read article >
#42. APOC3 may not be a predictor of risk of ischemic vascular ...
The genetic background of ischemic vascular disease is actively being explored. Several studies have shown that inhibition of APOC3 significantly reduces ...
#43. Apoc3 MGI Mouse Gene Detail - apolipoprotein C-III
Click on a disease name to see all genes associated with that disease. Mutations, Alleles, and. Phenotypes. less. Phenotype Summary. 16 phenotypes from 1 allele ...
#44. APOC3/A5 haplotypes, lipid levels, and risk of myocardial ...
Total cholesterol, triglyceride, and HDL cholesterol assays were standardized through the Centers for Disease Control Lipid Standardization ...
#45. APOC3 inhibition with volanesorsen reduces hepatic ...
... disease, and emerging therapeutic strategies-a consensus statement ... Targeting APOC3 in the familial chylomicronemia syndrome. N Engl J ...
#46. APOC3 Protein Is Not a Predisposing Factor for Fat- ...
Nonalcoholic fatty liver disease (NAFLD), characterized by excessive fat accumulation in liver, is prevalent in obesity. Genetic factors that ...
#47. The APOC3 gene homepage - Global Variome shared LOVD
View all diseases associated with gene APOC3 · Create a new disease information entry · View available phenotype columns · View all screenings ...
#48. Loss-of-function mutations in APOC3 and risk of ischemic ...
Loss-of-function mutations in APOC3 were associated with low levels of triglycerides and a reduced risk of ischemic cardiovascular disease.
#49. APOC3
Genetic variation in PNPLA3 but not APOC3 influences liver fat in non-alcoholic fatty liver disease. Journal of gastroenterology and hepatology. 2012 ...
#50. Loss-of-Function Mutations in APOC3 and Risk of Ischemic ...
BACKGROUND: High plasma levels of nonfasting triglycerides are associated with an increased risk of ischemic cardiovascular disease.
#51. Study of ARO-APOC3 in Healthy Volunteers ...
... APOC3 in healthy adult volunteers and in patients with severe hypertriglyceridemia and familial chylomicronemia syndrome (FCS). Condition or disease ...
#52. ApoC-III and ANGPTL3
Genetic association of APOC3 with lipoprotein metabolism and cardiovascular disease ... disease/ischemic heart disease. Three APOC3 mutations ...
#53. A phase 3 study to evaluate the efficacy and safety of ARO ...
A phase 3 study to evaluate the efficacy and safety of ARO-APOC3 in adults with familial chylomicronemia syndrome ... disease, with a prevalence of approximately ...
#54. APOC3 - apolipoprotein C3
The portal for rare diseases and orphan drugs · Search for a gene · APOC3 - apolipoprotein C3 · Diseases list.
#55. Apolipoprotein C3 Polymorphisms, Cognitive Function and ...
(2005) The APOC3 SstI polymorphism is weakly associated with sporadic Alzheimer's disease in a Chinese population. ... APOC3 gene and the metabolic syndrome in a ...
#56. RNA Interference Targeting Apolipoprotein C-III Results in ...
Target for Hypertriglyceridemia, Cardiovascular Disease. • Plasma triglyceride (TG) ... ARO-APOC3, a RNAi therapeutic designed to silence hepatocyte APOC3 mRNA.
#57. APOC3 mediated dyslipidemia in diabetic kidney disease ...
APOC3 is a key regulator of triglyceride-rich lipoprotein (TLR) metabolism. It is in turn regulated by insulin, but also by kidney disease. Our overall ...
#58. Loss-of-function mutations in APOC3, triglycerides, and ...
BACKGROUND: Plasma triglyceride levels are heritable and are correlated with the risk of coronary heart disease. Sequencing of the protein- ...
#59. Apolipoprotein C3 and Cardiovascular Disease in Patients ...
Background and Aims: Apolipoprotein C3 (ApoC3) is a key regulator of triglyceride metabolism via its inhibitory effects on lipolysis and ...
#60. Loss-of-function mutations in APOC3, triglycerides, and ...
BACKGROUND: Plasma triglyceride levels are heritable and are correlated with the risk of coronary heart disease.
#61. Association between apolipoprotein C3 Sst I, T-455C, C ...
Objectives Apolipoprotein C3 (ApoC3) polymorphisms have been suggested to be associated with risk of coronary heart disease (CHD). However, the results of ...
#62. Uncovering the role of apolipoprotein C-III in insulin ...
7,8 In fact, individuals with loss-of-function mutations in the APOC3 gene present lower triglyceride levels and a reduced risk of cardiovascular disease.
#63. A PRISMA-compliant meta-Analysis of apolipoprotein C3 ...
Background: The relationship between apolipoprotein C3 (APOC3) gene polymorphisms and nonalcoholic fatty liver disease (NAFLD) risk has been investigated in ...
#64. ApoCIII: A multifaceted protein in cardiometabolic disease
Keywords: APOC3 gene, ApoCIII protein, triglycerides, triglycerides (TG)-rich lipoproteins (TRL), APOC3 gene expression, cardiovascular disease risk, ...
#65. OMIA:002490-9986: Hyperlipidaemia/atherosclerosis, ...
(2021): "High levels of apolipoprotein C3 (APOC3) can lead to hypertriglyceridemia, which increases the risk of cardiovascular disease. ... An APOC3-KO ...
#66. Recent advances in treating hypertriglyceridemia in ...
The PubMed database was searched using terms: apolipoprotein C-III, ARO-APOC3, atherosclerotic cardiovascular disease, olezarsen, triglycerides, ...
#67. Loss-of-Function Mutations in APOC3, Triglycerides, and ...
Background—Plasma triglyceride levels are heritable and are correlated with the risk of coronary heart disease. Sequencing of the protein-coding regions of the ...
#68. APOC3 Mutations Tied to Low Triglycerides, Healthy Heart
(updated) High triglycerides rather than low HDL cholesterol may be a major culprit in heart disease, two large genetic studies suggest.
#69. APOC3 recombinant protein :: Apolipoprotein C-III ...
HALP2 is a condition characterized by high levels of high density lipoprotein (HDL) and increased HDL cholesterol levels. Belongs to the apolipoprotein C3 ...
#70. ARO-ANG3 External Manufacturing:
Apolipoprotein C3 (APOC3) regulates circulating levels of triglycerides (TGs) and lipoprotein metabolism by inhibiting lipoprotein lipase- ...
#71. Association between APOC3 polymorphisms and non- ...
Non-alcoholic fatty liver disease (NAFLD) is one of the most common cause of liver disease worldwide with prevalence varying from 15% to 40% in ...
#72. Dietary patterns interact with APOA1/APOC3 ...
Dietary patterns interact with APOA1/APOC3 polymorphisms to alter the risk of the metabolic syndrome: the Tehran Lipid and Glucose Study ...
#73. KEGG ORTHOLOGY: K08759
KEGG Orthology (KO) [BR:ko00001] 09150 Organismal Systems 09152 Endocrine system 03320 PPAR signaling pathway. K08759 APOC3; apolipoprotein C-III 09154 ...
#74. Western Dietary Pattern Interaction with APOC3 ...
The metabolic syndrome (MetS), a health problem characterized by insulin resistance, dyslipidemia, abdominal obesity and hypertension, is ...
#75. “Human Knockout Project:” Genetics in Families with First- ...
... Disease. April 12, 2017. rader saleheen. Daniel ... Compared with family members who were not APOC3 knockouts, the APOC3 knockout family members did not ...
#76. Study Reveals Links Between Lupus and Heart Disease
... disease risk factors were generally strongly associated with higher blood levels of ApoC3. However, lupus disease activity, severity and ...
#77. Loss-of-Function Mutations in APOC3, Triglycerides, and ...
Background Plasma triglyceride levels are heritable and are correlated with the risk of coronary heart disease. Sequencing of the protein-coding ...
#78. ApoCIII
APOC3, coronary disease, and complexities of Men- · delian randomization. Cell Metab. 2014 Sep 2;20(3):387–9. [99] Taskinen M-R, Borén J. Why ...
#79. Human Apolipoprotein CIII ELISA Kit (APOC3) (ab154131)
Human Apolipoprotein CIII ELISA Kit (APOC3) is a Sandwich (quantitative) ELISA for the measurement of Human Apolipoprotein CIII (APOC3) ... Involvement in disease.
#80. Associations of HDL Subspecies Defined by ApoC3 with ...
Abstract: Previously, we reported that inverse associations of high-density lipoprotein (HDL) with cardiovascular disease and diabetes were ...
#81. Association of APOC3 Loss-of-Function Mutations With ...
Footnotes. (BioImage Study: A Clinical Study of Burden of Atherosclerotic Disease in an At-Risk Population [BioImage Study]; NCT00738725).
#82. P485 Apolipoprotein C3 is Downregulated in Patients with ...
Inflammatory bowel disease (IBD) has been associated with an abnormal lipid profile. Apolipoprotein C3 (ApoC3) is a key molecule of triglycerides metabolism ...
#83. Disease activity in patients with rheumatoid arthritis ...
Apolipoprotein C-III (ApoC3) is a key molecule in triglycerides metabolism that has been linked to cardiovascular (CV) disease. Our objective ...
#84. Remnant cholesterol: a novel target for reducing lipid- ...
The low risk of ischaemic vascular disease associated with APOC3 loss-of-function (LOF) mutations is mediated by low remnant cholesterol not ...
#85. Day 2 Coverage
ApoC3 increases plasma triglycerides by inhibiting hydrolysis of ... disease risks, heart failure, and chronic kidney disease patients.
#86. Decreased expression of the APOA1–APOC3–APOA4 ...
Background: Apolipoprotein is genetically associated with the risk of Alzheimer's disease (AD). The APOA1, APOC3, and APOA4 genes are closely ...
#87. definition of APOC3 by Medical dictionary
... APOC3 (apolipoprotein C3) loss-of-function heterozygosity led to lifelong low triglycerides and consequently reduced ischemic cardiovascular disease (2, 6).
#88. Clinical Lipidology: A Companion to Braunwald’s Heart Disease
... APOC3 have significantly lower TG and higher HDL- C lev- els. Along with ... disease. These impressive find- ings from large genetic and population studies ...
#89. Allspring Global Investments Holdings LLC Has ...
... diseases associated with alpha-1 antitrypsin deficiency; ARO-APOC3, which is in phase 2b and one phase 3 clinical trial to treat ...
#90. Nutrition in the Prevention and Treatment of Disease
... APOC3 genotype significantly affected basal glucose concentrations and insulin concentrations after the test. Carriers of the S2 allele (n=13) had higher ...
#91. Comprehensive Cardiovascular Medicine in the Primary Care ...
... disease. Lancet (London, England). 2014;384:618–25. Rader DJ. New ... APOC3 confers a favorable plasma lipid profile and apparent cardioprotection. Science ...
#92. Clinical Management, Pathogenesis and Biomarkers of ...
... Disease duration, years CRP, mg/dl 2.4 (1.3-5.8) SLICC SLICC >=1, n (%) 1.9 ... ApoC3 remained significantly lower (beta coef. -1.2 [95%CI -1.6- -0.8) mg/dl ...
#93. Inherited Metabolic Disease in Adults: A Clinical Guide
... APOC3 inversion)4 and (2) concomitant deletion of the APOA1- C3- A4 gene cluster.5 Mutations involving apo A- I deletion are associated with increased ...
apoc3 disease 在 ESC 2020: APOC-III Reduction in Cardiovascular Disease 的推薦與評價
... disease. The administration of APOCIII -LRX in patients with hypertriglyceridemia and high CV risk was associated with inhibition of ApoC-III ... ... <看更多>