19MB055-Small Molecules that Inhibit the β - catenin /BCL9 InteractionAberrant Wnt pathway signaling is thought to be important for the growth ... ... <看更多>
beta -Catenin Inhibitors: Products ... beta-Catenin, also known as CTNNB1, is a cadherin-associated protein that is involved in the regulation of cell adhesion.
MSAB is a potent and selective inhibitor of Wnt/β-catenin signaling. MSAB binds to β-catenin promoting its degradation, and specifically downregulates Wnt/β- ...
beta -catenin Inhibitors ; IWP-2 · is an inhibitor of Wnt production, able to inactivate Porcn function by modulation of Porcn regulated active sites. ; β-Catenin/ ...
The Wnt/β-catenin Inhibitor, Cardamonin, also referenced under CAS 19309-14-9, controls the biological activity of Wnt/β-catenin. This small molecule/inhibitor ...
#11.
Targeting Wnt/β-Catenin Pathway for Drug Therapy
Carnosic acid, as mentioned above, has been shown to decrease transcriptional β-catenin. Chalcones such as derricin is newly discovered inhibitors of the Wnt ...
#12.
A small molecule inhibitor of β-catenin/cyclic AMP response ...
Inherited and somatic mutations in the adenomatous polyposis coli occur in most colon cancers, leading to activation of β-catenin-responsive genes.
#13.
β-Catenin/Tcf Inhibitor V, BC21 - CAS 691005-38-6 | 219334
β -Catenin/Tcf Inhibitor V, BC21 - CAS 691005-38-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available ...
MW 521.59, Purity > 98%. WIKI-4 is a potent inhibitor of Wnt/β-catenin signaling EC50 ~ 75 nM (in all cell lines tested including DLD1 colorectal cancer ...
#15.
ICG-001, an Inhibitor of the β-Catenin and cAMP Response ...
ICG-001, an Inhibitor of the β-Catenin and cAMP Response Element-Binding Protein Dependent Gene Transcription, Decreases Proliferation but Enhances Migration of ...
#16.
Direct targeting of β‐catenin in the Wnt signaling pathway ...
SAH-BCL9B can dissociate the β-catenin/BCL9 complex in cells, selectively suppress Wnt transcriptional activity, and inhibit proliferation, ...
#17.
Safety, tolerability, and anti-fibrotic efficacy of the CBP/β ...
A recent study showed that specific inhibition of the CREB-binding protein (CBP)/β-catenin interaction not only ameliorated but also reversed ...
Wnt binding to Frizzled (Fz) receptors and LRP co-receptors activates Dishevelled (Dsh) proteins; these in turn inhibit the destruction complex responsible for ...
#19.
Inhibitors of beta-Catenin Signaling - ChemDiv
Gigantol, a bibenzyl compound from orchid species, has also been reported to inhibit Wnt/β-catenin signaling through down-regulation of phosphorylated LRP6 and ...
#20.
Wnt/β-Catenin Inhibitor Dickkopf 1 - AHA Journals
The Wnt/β-catenin signaling pathway is an important mediator in cardiovascular disease and influences inflammation, vascular calcification, ...
#21.
Catenin beta-1 - Wikipedia
As a component of the complex, β-catenin can regulate cell growth and adhesion between cells. It may also be responsible for transmitting the contact inhibition ...
β-catenin-IN-2 is a potent β-catenin inhibitor, compound H1B1, extracted from patent US20150374662A1. β-catenin-IN-2 can be used for the study of colorectal ...
#23.
β-Catenin/Tcf Inhibitor II, PKF118-310 - Calbiochem | 219331
The β-Catenin/Tcf Inhibitor II, PKF118-310 controls the biological activity of β-Catenin/Tcf. This small molecule/inhibitor is primarily used for Cancer ...
#24.
A Potential Off-Target Effect of the Wnt/β-Catenin Inhibitor ...
Results: We have identified the potent Wnt/β-catenin inhibitor KYA1797K as a weak PD-L1 binder. Molecular docking suggested that the ...
#25.
A novel β-catenin/BCL9 complex inhibitor blocks oncogenic ...
Dysregulated Wnt/β-catenin signaling is implicated in the pathogenesis of many human cancers, including colorectal cancer (CRC), ...
#26.
iCRT5 Supplier | CAS 18623-44-4 - Focus Biomolecules
iCRT5 (CAS 18623-44-4) is a selective CRT inhibitor & it displays poor inhibition of cell proliferation in ... iCRT5 | Beta-catenin inhibitor.
ICG001 is a small molecule inhibitor that targets Wnt/β-catenin pathway. It inhibits TCF/β-catenin mediated transcription by competing with β-catenin for ...
#28.
The CREB-binding protein (CBP)/β-catenin inhibitor E7386 ...
E7386 is a CBP / β-catenin inhibitor that inhibits CBP and β-catenin protein-protein interactions and regulates the Wnt signal-dependent gene ...
#29.
Inhibition of Wnt signaling by ICAT, a novel β-catenin ...
Here, we identify a novel β-catenin-interacting protein, ICAT, that was found to inhibit the interaction of β-catenin with TCF-4 and represses ...
#30.
Inhibition of wnt/β-catenin Signaling in Hepatocellular ...
Inhibition of wnt/β-catenin Signaling in Hepatocellular Carcinoma by an Antipsychotic Drug Pimozide. Valerie Fako 1, Zhipeng Yu 1, Curtis J. Henrich 2, 3, Tanya ...
#31.
E7386, a Selective Inhibitor of the Interaction between β ...
It is difficult to directly target β-catenin itself by using a small molecule-compound inhibitor (23), but some inhibitors, such as ICG-001 and PRI-724, which ...
#32.
Wnt/β‑catenin inhibition reverses multidrug resistance in ...
Subsequently, Dickkopf-related protein 1 (DKK1) was used to inhibit the Wnt/β-catenin signaling pathway, and to abolish the resistance in BALL-1 ...
#33.
β-catenin inhibitors - AdooQ® Bioscience
Hexachlorophene is a potent KCNQ1/KCNE1 potassium channel activator with EC50 of 4.61 ± 1.29 uM; also is an inhibitor of Wnt/beta-catenin signaling.
#34.
Inhibition of Wnt/β-catenin signaling ameliorates osteoarthritis ...
Osteoarthritis (OA) is a degenerative joint disease involving both cartilage and synovium. The canonical Wnt/β-catenin pathway, ...
#35.
TIM-3 signaling hijacks the canonical Wnt/β-catenin pathway ...
As shown in Figures 2A-B, MEK1/2 inhibitor (U0126) or PI3K inhibitor (LY294002) could not inhibit the accumulation of β-catenin induced by TIM-3 ...
#36.
The regulation of β-catenin activity and function in cancer
As a receptor of Wnt, LRP6 acts as an inhibitor of GSK3β in response to Wnt stimulation [30]. Upon activation by Wnt, LRP6 is phosphorylated, ...
#37.
Direct Targeting of b-Catenin by a Small Molecule Stimulates ...
Suppresses Oncogenic Wnt/b-Catenin Signaling. Graphical Abstract. Highlights d. MSAB, a b-catenin inhibitor, was identified using cell-based.
#38.
Wnt/β-catenin signaling pathway is involved in induction of ...
Results: Oridonin inhibited the proliferation of colon cancer COLO205 cells in a dose-dependent and time-dependent manner. Oridonin induced apoptosis by ...
#39.
FogPharma Announces Selection of Clinical Development ...
... of small molecules; FOG-001, a first-in-class direct TCF-blocking β-catenin inhibitor, is on track to enter clinical development in 2023.
#40.
Modulation of β-Catenin Signaling by the Inhibitors of MAP ...
However, β-catenin-regulated transcriptional (CRT) activity is significantly inhibited by casein kinase II inhibitor DRB, MEK inhibitor PD98059, G-proteins and ...
to PI3K inhibition [37]. Adrenocortical tumors. Wnt/β-catenin activation has been shown to be an inde- pendent prognostic factor of overall and disease-free ...
#42.
Application of LY2090314, a Novel Selective Inhibitor ... - PLOS
Activating the Wnt/β-Catenin Pathway for the Treatment of Melanoma – Application of LY2090314, a Novel Selective Inhibitor of Glycogen Synthase Kinase-3.
#43.
Anti-tumor Activity of the Small Molecule Inhibitor PRI-724 ...
This study aimed to characterize β-catenin-activated hepatocellular carcinoma (HCC) and evaluate the direct effects of PRI-724 (a selective inhibitor of ...
#44.
Inhibitors of β-Catenin to B-Cell Lymphoma 9
Feng's group designed peptides based SAH-BCL9B, a previously reported peptide of the BCL9 homology domain 2 (BCL9-HD2) with promising inhibition ...
#45.
β-Catenin induces transcriptional expression of PD-L1 to ...
β -Catenin depletion, AKT inhibition, or PTEN expression reduces PD-L1 expression in tumor cells, enhances activation and tumor infiltration of ...
#46.
β-Catenin: oncogenic role and therapeutic target in cervical ...
Keywords: β-Catenin; Cervical cancer; Cell-cell adhesion; Wnt signaling pathway ... The inhibitor of β-catenin and TCF (ICAT) acts as a Wnt/β-catenin ...
#47.
NUCLEAR β-CATENIN INHIBITOR - TBL1 - A Novel Target for ...
Tegavivint (BC2059, Iterion Therapeutics) is a first-in-class small molecule inhibitor of TBL1 and the only TBL1 inhibitor reported to date. Tegavivint was ...
#48.
The GSK3 kinase inhibitor lithium produces unexpected ...
Turnover of β-catenin protein requires the phosphorylation of β-catenin by GSK3. Inhibition of GSK3 should lead to hypophosphorylation of β-catenin, increased ...
#49.
Inhibition of beta-catenin shows therapeutic potential in head ...
The small molecular compound MSAB was used to inhibit Wnt/Beta-catenin signaling in a human papillomavirus (HPV)-positive and HPV-negative cell ...
#50.
A small-molecule antagonist of the β-catenin/TCF4 ... - CORE
A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice. Cancer Res. 2012 ...
#51.
Inhibition of β-catenin signalling promotes DNA damage ...
Inhibition of β-catenin signalling promotes DNA damage elicited by benzo[a]pyrene in a model of human colon cancer cells via CYP1 ...
#52.
Small molecules in Wnt signaling - web.stanford.edu
Compound Target Inhibitor/activator. of the target Effect on signaling
WAY‑316606 SFRP Inhibitor activates
ABC99 Notum Inhibitor activates
IWP Porcupine Inhibitor inhibits
#53.
FAM46C suppresses gastric cancer by inhibition of Wnt/β ...
Activation of Wnt/β-catenin signaling pathway in GC cell lines quenched the effect of FAM46C overexpression. On the other hand, FAM46C silencing ...
#54.
(PDF) Allosteric inhibitor of β-catenin selectively targets ...
Allosteric inhibitor of β-catenin selectively targets oncogenic Wnt signaling in colon cancer. Springer Nature. May 2020; Scientific Reports 10(1).
#55.
IDENTIFICATION AND IN SILICO ANALYSIS OF INHIBITOR ...
Methods: Target genes involved in colon development were screened for specific genes in the Wnt/b-catenin signaling pathway. Tissue construction ...
#56.
Wnt/β-catenin inhibitor ICG-001 enhances the antitumor ...
Wnt/β-catenin inhibitor ICG-001 enhances the antitumor efficacy of radiotherapy by increasing radiation-induced DNA damage and improving ...
#57.
Wnt-β-Catenin Signaling in Human Dendritic Cells Mediates ...
Blockade of the Wnt/β-catenin pathway in DCs led to the selective inhibition of Treg without affecting the Th1 response.
#58.
Inhibition of the Wnt/β-catenin pathway enhances antitumor ...
Inhibition of the Wnt/β-catenin pathway enhances antitumor immunity in ovarian cancer. David W. Doo, Selene Meza-Perez, […] ...
#59.
Allele-specific endogenous tagging and quantitative analysis ...
Mutations in CTNNB1/β-catenin in colorectal cancer are typically found ... Moreover, treatment with a GSK3β inhibitor or introduction of a ...
A product comprising a stent for a human blood vessel which comprises (i) a scaffold which is impregnated with, adsorbed with, or coated with an inhibitor ...
#61.
Evaluation of β-Catenin Inhibition of Axitinib and Nitazoxanide ...
β -Catenin Inhibition of Axitinib and. Nitazoxanide in Human. Monocyte-Derived Dendritic Cells. Biomedicines 2021, 9, 949.
#62.
β-Catenin Signaling Drives Differentiation and ... - AAI Journals
β-Catenin–stabilized CD8α + DCs secreted elevated IL-12 upon in vitro microbial stimulation, and pharmacological β-catenin inhibition blocked this response in ...
#63.
The Role of Wnt5a and Hsp90 in the Wnt/Beta-Catenin ...
Treatment with Hsp90 inhibitor in the cell cause downregulation of β-catenin via GSK3β-dependent manner in Hsp90 inhibition leukemia cells and eventually ...
#64.
The many faces and functions of β‐catenin | The EMBO Journal
Potent Wnt pathway inhibitor and PORCN inhibitor. Suppresses R1 ESC self-renewal. Used in the production of cardiac organoids. Purity: >98%.
#67.
Metastatic Adrenocortical Carcinoma With Chromothripsis: A ...
It is a steroidogenesis inhibitor and adrenolytic drug used as adjuvant ... The canonical Wnt/β-catenin pathway, especially the β-catenin ...
#68.
Neuronal wiring diagram of an adult brain - bioRxiv
... Discovery and characterization of a specific inhibitor of serine-threonine ... 10.1101/2023.02.10.527983: Stabilisation of β-Catenin-WNT ...
#69.
Journal of the American Academy of Dermatology: Home Page
new diagnostic techniques, and; other topics related to the prevention, diagnosis, and treatment of disorders of the skin, hair, and nails. More ...
#70.
化学/材料, 药化类期刊, - X-MOL
Discovery of 1H-Imidazo[4,5-b]pyridine Derivatives as Potent and ... as the company advances a first candidate into the clinic to take on β-catenin.
#71.
pnu - Korea
... via inhibition of the interaction (KD50=450 nM) between β-catenin and ... DNA topoisomerase II inhibitor with excellent cytotoxicity.
#72.
Epidermal growth factor receptor compound and concomitant ...
... Epidermal growth factor receptor-tyrosine kinase inhibitor; ... and the CTNNB1 mutation could affect the Wnt/β-catenin pathway and ...
#73.
Pharmacology of the WNT Signaling System
... disruption of the BCL9/β-catenin complex inhibits oncogenic Wnt signaling. ... Kahn M (2005) Specific inhibition of CBP/beta-catenin interaction rescues ...
#74.
Wnt Signaling in Immune Cell Regulation During Microbial ...
Therefore, these data suggest that LP78 activates TLR2-Src to induce β-catenin activation. GW9662, an inhibitor of PPARγ (peroxisome proliferatoractivated ...
#75.
Mechanisms of Cellular Differentiation, Organ Development, ...
To further determine whether Wnt/β-catenin signaling inhibition could reverse the effects of HIF-1α knockdown on the NSC differentiation potential of hiPSCs ...
#76.
Catenins—Advances in Research and Application: 2013 Edition: ...
#77.
Introduction to Cancer Metastasis - 第 386 頁 - Google 圖書結果
Tcf has Asp residues and β-catenin contains hydrophobic pockets that show potential in ... The Tcf antagonist, inhibitor of beta-catenin and TCF (ICAT), ...
#78.
Management of Adrenal Masses in Children and Adults
4.2 Activation of the Wnt/ß-catenin signaling pathway in adrenocortical cancer factor ... Doghman et al. showed that Wnt/ß-- catenin inhibitor, PKF115–584, ...
#79.
Repurposed Drugs Targeting Cancer Signaling Pathways: ...
DRUGS THAT TARGET Wnt/β-CATENIN SIGNALING mammary tumors, it was observed that inhibition of Wnt/β- catenin pathway upregulates P62, LC3, ...
#80.
Natural Products as Less Toxic Antitumoral/Antiangiogenic ...
is different from drugs involving inhibition of TCF-dependent transcription in SW480 cells (Ewan et al., 2010). Interaction of ß- catenin with TCF binding ...
#81.
Index Medicus - 第 2530 頁 - Google 圖書結果
Lymphoid enhancer factor - 1 and beta - catenin inhibit Runx2- dependent ... in human hepatoma Hep3B cells by the phosphatase inhibitor orthovanadate .
#82.
Novel modalities in cancer diagnostics and therapeutics
(8) have shown that imatinib can inhibit tumor progression in ... Wnt/β-catenin inhibitor tegavivint is a new type of targeted drug and is being studied.
beta-catenin inhibitor 在 Mark Ji - 19MB055-Small Molecules that Inhibit the β-catenin ... 的推薦與評價
19MB055-Small Molecules that Inhibit the β - catenin /BCL9 InteractionAberrant Wnt pathway signaling is thought to be important for the growth ... ... <看更多>