由 E Martin-Orozco 著作 · 2019 · 被引用 100 次 — In fact, WNT signaling is associated with the onset of many types of solid and liquid tumors. As an example, mutations involved in the WNT ...
The Wnt signaling pathway is critical for the regulation of cell proliferation, differentiation, apoptosis and migration. Mutations in the Wnt gene or Wnt ...
1987). Although wnt was the prototypical oncogene in this pathway, no formal proof for its involvement in human cancer has ever been documented. There have been ...
Wnt5a mediated noncanonical Wnt pathway also has been shown to alter cell energy metabolism directly in breast cancer cells [77]. Another noncanonical Wnts such ...
#11.
Wnt signaling pathway - Wikipedia
Canonical Wnt pathway activity is involved in the development of benign and malignant breast tumors. The role of Wnt pathway in tumor chemoresistance has been ...
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Special Issue : Wnt Signaling in Cancer - MDPI
Mutations in components of the Wnt/β-catenin signaling pathway drive colorectal cancer (CRC) by deregulating expression of downstream target genes including the ...
#13.
Wnt signaling pathway and its role in cancer and patterning of ...
Wnt signaling pathway and its role in cancer and patterning of the brain. 10,503 views10K views. Jul 8, 2018.
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Role of the Wnt Signaling Pathway and Lung Cancer - Journal ...
The Wnt pathway plays an important role in development and in regulating adult stem cell systems. A variety of cellular processes are mediated by Wnt signaling, ...
#15.
Canonical and non-canonical WNT signaling in cancer stem ...
Intra-tumor heterogeneity and cancer-cell plasticity give rise to therapeutic resistance and recurrence through clonal replacement and ...
#16.
Signaling by WNT in cancer - Reactome
The WNT signaling pathway has been linked with cancer ever since the identification of the first WNT as a gene activated by integration of mouse mammary ...
#17.
The role of Wnt signaling pathway in tumor metabolic ...
Wnt signaling pathway is one of the critical signaling pathways regulating cell proliferation and differentiation. In recent years, it has been found that Wnt ...
#18.
Targeting the Wnt Pathway in Cancer | SpringerLink
Provides an overview of the Wnt pathway as a therapeutic target for cancer. Discusses the preclinical development of inhibitors specifically directed to ...
#19.
New Advances in Canonical Wnt/β-Catenin Signaling in Cancer
Wnt signaling is involved in the malignant progression of breast cancer, such as proliferation, invasion, metastasis, and drug resistance. In ...
#20.
The Wnt signaling pathway: a potential therapeutic target ...
The Wnt pathway is prominently involved in several aspects of tumorigenesis. Wnts evoke a wide range of responses from cell division to ...
#21.
The physiological role of Wnt pathway in normal development ...
Additionally, we will briefly introduce new strategies currently in clinical trials targeting Wnt signaling pathway components for cancer ...
#22.
Targeting the Wnt signalling pathway in cancer - Swiss ...
Apart from its involvement in tumourigenesis and cell proliferation, the Wnt pathway contributes to chemoresistance and cancer stem cell (CSC) ...
#23.
Hard-to-Target WNT Pathway Gets a Fresh Look in Oncology
WNT signaling abnormalities have been found across a range of other cancer types and in a variety of pathway components. An estimated 25% to 35% ...
#24.
Small-Molecule Inhibitors Targeting the Canonical WNT ...
(31,32) WNT signaling pathways are activated in more than 50% of breast cancer patients and associated with a reduction in overall survival. (33) ...
#25.
WNT and β-Catenin in Cancer: Genes and Therapy - Annual ...
The WNT pathway is a pleiotropic signaling pathway that controls developmental processes, tissue homeostasis, and cancer. The WNT pathway is commonly ...
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enhanced WNT/β-catenin signaling by high glucose in
Hyperglycemia could therefore ensure a high glucose supply for cancer cells favoring anabolic cancer metabolism to fuel tumor growth and thereby explain the ...
#27.
Wnt signaling in Cancer | The Wnt Homepage
Several components (colored in the figure) of the Wnt signaling pathway have been implicated in human tumors or experimental cancer models.
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Beta-Catenin/WNT signaling - My Cancer Genome
Overview. The β-catenin/WNT cell signaling pathway promotes the activation of gene transcription to mediate pleiotropic effects including cell growth and ...
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The roles of Wnt/β-catenin signaling pathway related lncRNAs ...
WNT signaling can promote or inhibit tumor initiation, growth, and metastasis and drug resistance in a cancer stage-specific or a cancer type-specific manner[25] ...
#30.
The Wnt/β-catenin signaling pathway targets PPARγ activity in ...
The Wnt/β-catenin signaling pathway targets PPARγ activity in colon cancer cells. Emmelie Å. Jansson, Alexandra Are, Gediminas Greicius, I-Chun Kuo ...
#31.
WNT Signaling in Cancer Immunosurveillance - Cell Press
Deregulated WNT signaling has been shown to favor malignant transformation, tumor progression, and resistance to conventional cancer therapy ...
#32.
WNT inhibition creates a BRCA‐like state in Wnt‐addicted ...
Wnt signaling maintains diverse adult stem cell compartments and is implicated in chemotherapy resistance in cancer. PORCN inhibitors that block Wnt ...
#33.
WNT Signaling: an Emerging Mediator of Cancer Cell ...
Active WNT signaling is linked to alterations in cancer cell metabolism. Transcriptional changes induced through WNT-mediated stabilization of β ...
#34.
Role of Wnt/β-Catenin Signaling in the Chemoresistance ...
Colorectal cancer (CRC) is a common malignancy with high morbidity and mortality worldwide. To date, chemotherapy plays an important role in ...
#35.
The Potential of Wnt Signaling Pathway in Cancer: A Focus on ...
In breast cancer condition, convincing results are available wherein the Wnt pathway activation in breast cancer cells increases the cell motility while its ...
#36.
Wnt-pathway Activating Mutations Are Associated with ...
Wnt -pathway activation may accelerate prostate cancer androgen-independent growth and mediate antiandrogen resistance.
#37.
The canonical Wnt signalling pathway and its APC partner in ...
Canonical Wnt signalling has received considerable attention from cancer researchers over the years, because of its essential role in the homeostasis of the ...
#38.
Wnt Signaling Pathway in Non–Small Cell Lung Cancer | JNCI
Wnt /β-catenin alterations are prominent in human malignancies. In non–small cell lung cancer (NSCLC), β-catenin and APC mutations are uncommon, but Wnt ...
#39.
Targeting Wnt signaling in colorectal cancer. A Review in the ...
The Wnt signaling pathway is aberrantly upregulated in both MSS and MSI CRCs (12). Inactivating mutations of the negative regulator APC constitute the principal ...
#40.
Highly immunogenic cancer cells require activation of the ...
Here, we showed that activation of the WNT/β-catenin signaling pathway contributed to the development of a noninflamed TME in tumors with ...
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Signaling by WNT in cancer Gene Set - Ma'ayan Laboratory ...
212 proteins participating in the Signaling by WNT in cancer pathway from the Reactome Pathways dataset. Symbol, Name. AES, amino-terminal enhancer of split.
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Targeting the canonical Wnt/β-catenin pathway in cancer ...
It is currently acknowledged that the activation of the canonical Wnt signaling pathway can promote tumor cell differentiation, and ...
#43.
Inhibition of Wnt Signaling Pathway Decreases Chemotherapy ...
Most sporadic colorectal tumors involve constitutive activation of the Wnt signaling pathway through mutations of APC or β-catenin (16, 20). For example, a ...
#44.
Light can trigger key signaling pathway for embryonic ...
An artist's rendering of Wnt proteins in a cell membrane ... triggering the Wnt pathway, important in embryonic development and cancer.
#45.
WNT signaling increases proliferation and impairs ...
In addition, WNT pathway mutations are associated with medulloblastoma, the most common malignant brain tumor in children. However, the cell ...
#46.
Wnt/β-Catenin Signaling
Expert-reviewed interactive pathways providing current overviews of Wnt, ... in tumor samples, underscoring the deregulation of this pathway in cancer. Wnt ...
#47.
Wnt Signaling Pathway - Creative Diagnostics
The Wnt signaling pathway is an ancient and evolutionarily conserved pathway that regulates crucial aspects of cell fate determination, cell migration, cell ...
#48.
Targeting the Versatile Wnt/β-Catenin Pathway in Cancer ...
The characterization of the Wnt/β-catenin signaling pathway and the revelation that many cancers habor mutations in members of this pathway make ...
#49.
Wnt Pathway Activity in Breast Cancer Sub-Types and Stem ...
Wnt pathway signalling increased in cancer compared to normal breast and in both cell lines and patient samples, expression of Wnt pathway ...
#50.
The role of Wnt signaling in cancer and stem cells - Future ...
The Wingless-Int (Wnt) signaling pathway has been widely investigated in recent years. Initially, its role regulating cell proliferation and survival during ...
#51.
Wnt signaling as potential therapeutic target in lung cancer
Expert opinion: Wnt signaling plays an important role in the development and metastasis of lung cancer; the pathway provides targets to develop agents towards ...
#52.
Targeting the WNT Signaling Pathway in Cancer Therapeutics.
WNT pathway -inactivating mutations remain to be seen in cancer. Colorectal cancer (CRC) epitomizes the mutational aberrations of hyperactivated WNT signaling.
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SOX9 drives WNT pathway activation in prostate cancer - JCI
Finally, treatment of SOX9-expressing PCa cells with a WNT synthesis inhibitor (LGK974) reduced WNT pathway signaling in vitro and tumor growth ...
#54.
Epigenetic alterations of the Wnt signaling pathway in cancer
One of the key signaling pathways whose components are altered through the epigenetic mechanisms is the Wnt signaling pathway.
#55.
Wnt signaling in cancer stem cells and colon cancer metastasis
Overactivation of Wnt signaling is a hallmark of colorectal cancer (CRC). The Wnt pathway is a key regulator of both the early and the later ...
#56.
Targeting the Wnt Pathway in Cancer eBook - Amazon.com
Inappropriate activation of the Wnt signaling pathway is observed in many human cancers and is sufficient to drive tumor initiation and progression in ...
#57.
Wnt Signalling Pathway - News Medical
Wnt signalling is an important, evolutionarily conserved signalling pathway that determines cell ... The Wnt/β-catenin signaling pathway
#58.
Targeting the Wnt Pathway in Cancer - 第 173 頁 - Google 圖書結果
Another non-canonical Wnt pathway that has been demonstrated to inhibit Wnt ... TCF sites available for b-catenin binding in a range of cancer cell lines.
#59.
Wnt signaling is identified as a target in NEDAMSS disorder
The Wnt pathway, the human counterpart of the Wingless pathway in flies, ... Wnt/Wingless signaling pathway is perturbed during development.
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Author Manuscript - Serval
To explore if the Wnt signaling pathway has a role in modulating mature T cell responses, we first measured relevant gene expression levels in naïve, ...
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Merck Serono, ICR, Wellcome Trust in Cancer Drug Discovery ...
“We will build on a joint compound base of potent tankyrase inhibitors and will leverage both sites' scientific knowledge about the 'Wnt pathway ...
#62.
Chan 144 pk - The Dream Body
Aberrant methylation of the Wnt antagonist SFRP1 in breast cancer is associated with unfavourable prognosis. 7, respectively; p=0.
#63.
Oncology clinical pathways examples. The shift away from ...
The Guideline Resource Unit (GURU) coordinates the development of guidelines for cancer treatment and follow The aberrant Wnt/β-catenin signaling pathway ...
#64.
SIGNOR 2.0
SIGNOR, the SIGnaling Network Open Resource, organizes and stores in a structured ... Toll like receptors, VEGF Signaling, Vitamin-K cycle, WNT Signaling.
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Abiraterone Acetate Articles - UroToday
... abiraterone) in combination with prednisone in post-docetaxel mCRPC. ... of Prostate Cancer Metastases Reveals Association of Wnt Pathway Activation and ...
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BRD4-directed super-enhancer organization of transcription ...
chemotherapeutic efficacy in breast cancer ... WNT pathways that are critically involved in cell proliferation,.
#67.
Wnt signaling is identified as a target in NEDAMSS disorder in ...
The Wnt pathway, the human counterpart of the Wingless pathway in flies, ... Wnt/Wingless signaling pathway is perturbed during development.
#68.
A Landscape of Pharmacogenomic Interactions in Cancer
alterations in cancer points to a hierarchy of likely functional pro- ... pathway. WNT. Signaling. Metabolism. Genome. Integrity.
An overview of the latest developments in stem cell biology, gene therapy and ... Invastigating the role of non canonical WNT signaling pathway in Multiple ...
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Cholangiopathies and the noncoding revolution
miR-34a has a well recognized role in cancer and liver diseases and is ... by regulating the Wnt-signaling pathway through direct targeting of WNT2B.
#71.
Impact of PCBs, Furan and Dioxin on Hepatocarcinogenesis
In 1987, International Agency for Research on Cancer and in 1996, the US environmental Protection Agency ... The main targeted pathways were Wnt and TGF-β.
#72.
Vivo Expansion of Fully Functional Salivary Gland Stem Cells
tion damage in head and neck cancer patients after radiotherapy. ... stem-cell-maintenance-related Wnt pathway (Baker,.
#73.
乳腺浸润性导管癌组织IRS1、PRSS3蛋白表达与磷酸化蛋白 ...
PI3K/AKT/mTOR Signaling Pathway in Breast Cancer: From Molecular Landscape to ... formation and Wnt/β-catenin signaling in breast cancer[J].
... independently of the Wnt/β-catenin signalling pathway https://t.co/ZeztjZcXSl ... Pan-cancer association of DNA repair deficiencies with ...
#75.
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A novel signaling pathway for GDF-15 through interaction with the ... disc (IVD) cells and to examine whether Wnt–β-catenin signaling regulates the ...
#76.
Publications 2009 - CECAD Cologne
Treatment of invasive fungal infections in cancer ... Small molecule inhibitors of WNT signaling effectively induce apoptosis in acute myeloid leukemia ...
#77.
Wnt Signaling – NK Cells for Adoptive Immunotherapy
Wnt Signaling. Wnt Signaling ... cells and intestinal bacteria, to promote or inhibit colorectal cancer cell proliferation have been reported recently.
WEHI researchers have identified an enzyme in the thymus that is essential for immune T cells to correctly identify threats, ...
#79.
The H19 Non-Coding RNA Is Essential for Human Tumor ...
activation of WNT/b-catenin pathway through CTNNB1/ b- ... importance of the Twist gene product in tumor metastasis, the.
#80.
G2a dharma - csia-gorizia.it
This might be the wildest rollout we will ever see in this lifetime yall ... as a Wnt-induced intracellular negative regulator of canonical Wnt signaling.
#81.
部分机构医学科研诚信案件调查处理结果（2021年12月29日）
... an oncogene in human colorectal cancer by targeting miR-132-3p ”，经查， ... Colorectal Cancer via Regulation of Wnt-/β-Catenin Signaling Pathway”，经 ...
#82.
Exact trader funding. Same-day funding not available for co ...
Catalio Capital Management was created by George Petrocheilos and Dr. In the alternative Wnt pathway, YAP/TAZ is the critical medium.
#83.
Axcelead Begins Joint Research with Tokyo Medical and ...
In this joint research, we aim to obtain mRNA therapeutics candidates by further developing the TMDU's previous research activities, optimizing ...
#84.
Episode 21-36 A two-week anti depression treatment?
First up, treating depression in a whole new way … and rapidly. ... talks about their work with the W-N-T pathway, or Wnt pathway.
#85.
NIH Public Access - CORE
In all eukaryotes, the target of rapamycin (TOR) signaling pathway couples energy and nutrient ... Moreover, the Wnt pathway has been implicated in mTORC1.
#86.
Pathway licensee. The pathway is named for the WNT ligands ...
The pathway is named for the WNT ligands, a large family of secreted ... (MHRA) has announced that a treatment for a rare cancer-causing genetic disorder is ...
#87.
Society phoenix apartments. Located at the crest of Jubilee ...
19 salaries for 15 jobs at American Cancer Society in Phoenix, AZ Area. Close to Shopping. You can reach him any time by calling or texting 480-571-8650 to ...
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American research labs raloxifene. Methods Participants were ...
Breast Cancer Research in Dr. Lilly Research Laboratories sionals from the ... and adipogenesis through Wnt regulation in ovariectomized rats and 3T3-L1 ...
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Embo 2022. The EMBO Journal Impact Factor IF measures the ...
The Canary Center at Stanford for Cancer Early Detection is committed to ... Whereas several types of Wnt meetings have been held almost every year in ...
#90.
Hair-bearing human skin generated entirely from pluripotent ...
Extended Data Figure 1 | Overview of skin organoid induction in relation to normal ... Genes encoding WNT signalling pathway modulators were ...
#91.
Dtp phd. We strongly recommend that you read the How to ...
VanHoose received her Master of Science in Physical Therapy degree from the ... British Heart Foundation, Cancer Research UK, and the Wellcome Trust.
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