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#1. Epithelial Mesenchymal Transition in Tumor Metastasis
由 V Mittal 著作 · 2018 · 被引用 496 次 — Epithelial mesenchymal transition (EMT), an evolutionarily conserved developmental program, has been implicated in carcinogenesis and confers ...
#2. EMT, MET, Plasticity, and Tumor Metastasis - Cell Press
To demonstrate that metastasis occurs in an EMT-independent fashion might require the ability to track Ecad expression and cellular localization ...
#3. Context-dependent EMT programs in cancer metastasis
The EMT/MET model of metastatic dissemination attempts to reconcile the seemingly contradictory observation that metastatic lesions tend to have epithelial ...
#4. EMT in Metastasis: Finding the Right Balance - ScienceDirect
由 HC Lo 著作 · 2018 · 被引用 37 次 — The epithelial-to-mesenchymal transition (EMT) is a key driver of cancer metastasis. In this issue of Developmental Cell, Aiello et al.
#5. Epithelial–mesenchymal transition - Wikipedia
Thus, EMT and MET form the initiation and completion of the invasion-metastasis cascade. ... At this new metastatic site, the tumor may undergo other processes to ...
#6. Epithelial Mesenchymal Transition in Tumor Metastasis
Epithelial mesenchymal transition (EMT), an evolutionarily conserved developmental program, has been implicated in carcinogenesis and confers metastatic ...
#7. and Post-EMT Tumor Cells in Breast Cancer Metastasis
Metastases are responsible for the majority of breast cancer–associated deaths. The contribution of epithelial-to-mesenchymal transition (EMT) in the ...
#8. A landscape view on the interplay between EMT and cancer ...
Cancer metastasis, as the most fatal stage of cancer, accounts for over 90% of cancer deaths. ... The epithelial–mesenchymal transition (EMT) ...
#9. Contextual extracellular cues promote tumor cell EMT and ...
Metastatic disease is a primary cause of cancer-related death, and factors governing tumor cell metastasis have not been fully elucidated. Here, we address this ...
#10. New Insights Into the Role of Phenotypic Plasticity and EMT in ...
In addition to cellular migration during metastasis, EMT also influences resistance to ...
#11. EMT, cell plasticity and metastasis - Prof. Elgene Lim
Keywords EMT . Cancer cell plasticity . Metastasis . Partial-EMT . Tumor-initiating cells (TICs). 1 Introduction. The acquisition of mesenchymal cell traits ...
#12. Epithelial-Mesenchymal Transition (EMT) as a Therapeutic ...
Metastasis is the spread of cancer cells from the primary tumour to distant sites and organs throughout the body. It is the primary cause of cancer ...
#13. Vimentin Is at the Heart of Epithelial Mesenchymal Transition ...
Its active role in EMT, angiogenesis, cancer stem cells population maintenance, cancer invasion, metastasis, chromosome instability and.
#14. Cisplatin prevents breast cancer metastasis through blocking ...
Two recently published studies indicated that EMT is dispensable for metastasis when tested in two animal models [9, 10], whereas a more recent study revealed ...
#15. Dynamic Monitoring of EMT in CTCs as an Indicator of Cancer ...
Epithelial to mesenchymal transition (EMT) results in the genesis of ... of EMT-associated phenotypes in CTCs, to monitor cancer metastasis.
#16. CDCA4 suppresses epithelial–mesenchymal transtion (EMT ...
CDCA4 suppresses epithelial–mesenchymal transtion (EMT) and metastasis in Non-small cell lung cancer through modulating autophagy · Abstract ...
#17. Epithelial–mesenchymal plasticity: emerging parallels ...
Cancer metastasis is a complex, multistage process, and there is increasing ... Many EMT-TFs were first identified for their role in tissue ...
#18. Epithelial-mesenchymal transition in cancer: An overview
EMT and the metastatic process ... Metastasis is a process defined when cells of the primary tumor break off, entering the bloodstream and/or lymph vessels and ...
#19. CTEN induces epithelial-mesenchymal transition (EMT) and ...
CTEN induces epithelial-mesenchymal transition (EMT) and metastasis in non small cell lung cancer cells. Xiangdong Lu ,.
#20. A novel form of cancer therapy: Targeting metastatic EMT (video)
By Michael Lai This video discusses the biological phenomenon known as the Epithelial-Mesenchymal Transition (EMT) and the role it plays in driving metastasis.
#21. The metastatic cascade. The EMT is involved in early steps of ...
EMT programs are dynamically regulated. During colonization, the last step of the metastatic cascade, carcinoma cells are thought to switch back to an ...
#22. Cancer: Tumour driver promoting EMT, metastasis and ...
Cancer: Tumour driver promoting EMT, metastasis and resistance to therapy. Cancer metastasis, which is the dissemination of tumour cells ...
#23. Epithelial-Mesenchymal Transition and its Impact on Tumor ...
Together, these cellular and molecular changes also promote the occurrence of EMT processes and EMT phenotypes. The molecular mechanism of tumor metastasis ...
#24. SKA2 mediates invasion and metastasis in human breast ...
However, the specific regulatory mechanism mediating EMT and SKA2 in breast cancer progression remains to be investigated. In the present study, ...
#25. Epithelial-mesenchymal transition leads to NK cell–mediated ...
Depletion of NK cells allowed spontaneous metastasis without affecting primary tumor growth. EMT-induced modulation of E-cadherin and cell adhesion molecule 1 ( ...
#26. Upholding a role for EMT in pancreatic cancer metastasis
Epithelial-to-mesenchymal transition (EMT) is a cellular program that operates in the context of embryogenesis, wound healing and carcinoma pathogenesis to ...
#27. EMT and MET: necessary or permissive for metastasis? | bioRxiv
Here, we focus on epithelial-mesenchymal plasticity in metastatic ... dissemination and metastases beyond the traditional EMT-MET view.
#28. Hippo signalling in EMT and metastasis | Journal of Cell Science
EMT also occurs during tumour progression and facilitates the metastatic spread of cancer cells. The Hippo tumour suppressor signalling ...
#29. Epithelial-Mesenchymal Transition and its Regulation in ...
4. EMT and tumor metastasis. Through the blood or lymphatic system, tumor cells can migrate far from the primary site and then settle and grow in a remote ...
#30. Implications of the hybrid epithelial/mesenchymal phenotype ...
(EMT) and its reverse MET. EMT marks the first step of 'invasion-metastasis cascade' where epithelial cells of the primary tumor lose their cell-cell ...
#31. A FASN-TGF-β1-FASN regulatory loop contributes to high ...
Figure 1: EMT and metastatic potential were increased in ... Figure 3: Inhibition of FASN reduced EMT/metastasis potential of ...
#32. Transcription factor PREP1 induces EMT and metastasis by ...
Transcription factor PREP1 induces EMT and metastasis by controlling the TGF-β–SMAD3 pathway in non-small cell lung adenocarcinoma · Significance.
#33. EMT regulator slug and lung carcinogenesis
Cancer metastasis and resistance to treatment (including radiotherapy, chemotherapy and targeted therapy) are two major causes for the poor survival of lung ...
#34. EMT activation in tissue growth is also at play in cancer ...
“The problem is that EMT is also activated in various disease processes, such as fibrosis and cancer metastasis,” said Smyth, who is also an ...
#35. Reversible EMT and Metastasis | Taube Lab - Sites @ Baylor ...
Epithelial-mesenchymal transition (EMT) enhances metastatic dissemination while partial EMT or reversal of EMT facilitates growth of metastases.
#36. The Other EMT: Exploring the controversial driver of metastasis
EMT was the leading explanation for how and why metastasis happens. The idea began with studies that showed how epithelial tumor cells that had ...
#37. Annexin10 promotes extrahepatic cholangiocarcinoma ...
ANXA10 promoted the progression of PHCCA and facilitated metastasis by promoting the EMT process via the PLA2G4A/PGE2/STAT3 pathway. ANXA10, ...
#38. Metastases May Be Powered by Cell Transformation EMT
The cell transformation known as epithelial-mesenchymal transition may allow cancer cells to break away from the tumor and spread elsewhere.
#39. Functional inactivation of E-cadherin drives EMT-less metastasis
Pre-clinical models of orthotopic growth of colon cancer and metastatic diffusion to the liver were utilized. Xenotransplant transcriptome analysis assessed EMT ...
#40. Probing the Fifty Shades of EMT in Metastasis - Princeton ...
Epithelial-to-mesenchymal transition (EMT); cancer metastasis; plasticity; in vivo tracing. The metastatic dissemination of epithelial tumors has been ...
#41. Post-translational modifications of EMT transcriptional factors ...
Epithelial– mesenchymal transition (EMT) is a dynamic process that appear to facilitate tumor metastasis in various cancers by switching epithelial cells into ...
#42. Epithelial to mesenchymal transition (EMT) tools | Abcam
Decreased E-cadherin expression is a fundamental event in EMT and cancer metastasis and has emerged as a molecular hallmark of the carcinoma EMT.
#43. The role of EMT-related lncRNA in the process of triple ...
... ZEB2-AS1 promoted TNBC metastasis by regulating EMT process.
#44. MicroRNA-200c modulates epithelial-to-mesenchymal ... - Gut
... transition (EMT) in human colorectal cancer metastasis ... miR-200c plays an important role in mediating EMT and metastatic behaviour in the colon.
#45. EMT and tumor metastasis - Clinical and Translational Medicine
in both tumor cells and stromal cells, which play a role in EMT and metastasis. We further delve into the clinical implications of EMT and MET in several ...
#46. Selumetinib Inhibits Melanoma Metastasis to Mouse Liver via ...
TGFβ1 is critical for EMT during tumor metastasis, and EMT results in the change in expression of many genes. Thus, to confirm the inhibition of cancer cell ...
#47. Epithelial-mesenchymal transition, invasion, and intravision
We'll describe the major theories of metastasis and then describe the biology behind the steps in ... Introduction to EMT / Invasion / Intravasation1:16.
#48. A Transient, EMT-Linked Loss of Basement Membranes ...
However, the BM is still expressed in most typical colorectal adenocarcinomas; nevertheless, these tumors can invade and develop metastases. The aim of this ...
#49. EMT imparts cancer stemness and plasticity - Bioscience ...
Cancer metastasis is driven by EMT mainly by conversion of cancer cells ...
#50. Partial EMT in Squamous Cell Carcinoma: A Snapshot
EMT endows tumors with malignant properties, including aggressive behaviors, metastasis, cancer stem cell (CSC) activity, and therapeutic resistance [2].
#51. 1977O Functional inactivation of E-cadherin drives EMT-less ...
Pre-clinical models of orthotopic growth of colon cancer and metastatic diffusion to the liver were utilized. Xenotransplant transcriptome analysis assessed EMT ...
#52. Mechanism and regulation of epithelial–mesenchymal ...
It is hypothesized that EMT plays a major role in tumor invasion and the establishment of distant metastases. Metastatic disease is ...
#53. EMT and tumor metastasis - Harvard DASH
in both tumor cells and stromal cells, which play a role in EMT and metastasis. We further delve into the clinical implications of EMT and MET in several ...
#54. EMT reporter cell lines: Elevating biological models of ...
Epithelial-to-mesenchymal transition (EMT), important in many ... in the involvement of EMT and MET in cancer progression and metastasis.
#55. Signaling Pathways and Molecular Mediators in Metastasis
Neutralizing antibodies to the beta1 integrin subunit and pharmacological inhibition of beta3 integrin subunit also inhibits induction of EMT [124, 125].
#56. EMT and stem cells : roles in the formation of cancer and ...
EMT and stem cells : roles in the formation of cancer and metastases. Julie Caramel, researcher in Pr Alain Puisieux team at the Cancer Research Center of ...
#57. Tumor Metastasis - 第 222 頁 - Google 圖書結果
invasion and metastasis of cells. The loss of E-cadherin expression has been considered the most notable feature of EMT [36]. EMT presents increased ...
#58. The rejuvenated scenario of epithelial–mesenchymal ...
Due to the close relationship of EMT to cancer metastasis and chemoresistance, targeting EMT or reversing EMT is likely to lead to novel ...
#59. Epithelial mesenchymal transition (EMT) - Prof. Sima Lev
EMT · Sima Lev · Previous. Lipid transfer proteins in cancer biology & metastasis · Next. Epithelial-mesenchymal transition (EMT) ...
#60. The Epithelial-to-Mesenchymal Transition (EMT) in Cancer
EMT endows CTCs with mesenchymal phenotypes, and is an early event in the metastatic process. Thus it is conceivable that EMT marker detection in CTCs may ...
#61. Bladder Cancer: Diagnosis and Clinical Management
eMt. in. “stemness”. and. metastasis. As discussed above, there is evidence that basal and luminal cancers may arise from phenotypically distinct cancer ...
#62. Osmolytes induce kidney EMT | BioWorld
EMT is a major event in tumor progression with metastatic ... In acute and chronic kidney injuries, EMT of tubular epithelial cells (TECs) ...
#63. Doxorubicin promotes breast cancer cell migration and ...
... and the epithelial-mesenchymal transition (EMT) in human breast cancer, ... may increase the risk of metastasis of drug-resistant breast cancer cells, ...
#64. Effects of VCP979 Novel p38 Mitogen Activated Protein ...
... of tumor development, metastasis, and response to VCP979. ... (EMT) in pancreatic cancer non-diabetic and diabetic conditions.
#65. Colorectal Cancer Biomarkers for Drug Sensitivity - DocWire ...
Their investigation included 2250 primary and metastatic human CRC ... with epithelial to mesenchymal transition (EMT), regional metastasis, ...
#66. MOESM2 of CircPTK2 (hsa_circ_0005273) as a novel ...
MOESM2 of CircPTK2 (hsa_circ_0005273) as a novel therapeutic target for metastatic colorectal cancer.
#67. Geert BERX - Irc Ugent
Epithelial-mesenchymal transition (EMT) is a natural process of reshaping epithelia ... features needed to execute the entire invasion-metastasis cascade.
#68. Hypoxia and Cancer Metastasis - 第 47 頁 - Google 圖書結果
... loss of BCSCs and reduced tumorigenic and metastatic potential of BCSCs [59]. ... 3.3.5 HIF Signaling, EMT and CSC The epithelial to mesenchymal (EMT) ...
#69. Venkata Lokesh Battula | MD Anderson Cancer Center
... chemo-resistance, tumor initiation and metastasis of cancer stem cells. ... Epithelial-to-mesenchymal transition (EMT) has been shown to induce stem ...
#70. 医疗机构医学科研诚信案件调查处理结果(2021年12月15日)
... 通讯作者及第一作者的论文“MiR-150 alleviates EMT and cell invasion ... HOST2 enhances proliferation and metastasis in gastric cancer”。
#71. Novel technique developed to observe cancer cells' metastatic ...
When cancer cells metastasize, they morph, becoming missile-shaped in order to ... called epithelial to mesenchymal transition, or EMT, can significantly ...
#72. Ibrutinib is Burton's tyrosine kinase inhibitor used in the ...
4T1-Luc tumor challenged mice were analyzed for lung metastasis by injecting India ... ITK (interleukin-2-inducible T-cell kinase)/EMT/TSK, BMX and TXK/RLK.
#73. Dr. Zea Borok, MD | San Diego, CA | Pulmonologist - US News ...
EMT and Interstitial Lung Disease: A Mysterious Relationship ... Regulation of breast cancer metastasis by Runx2 and estrogen signaling: the role of SNAI2.
#74. DNA甲基化seq简介- 生物慕课的日志- 网易博客
... 结果显示与EMT过程相关的促细胞侵袭基因(pro-invasive EMT-associated ... by miR-146a/b modulates gastric cancer invasion and metastasis.
emt metastasis 在 EMT reporter cell lines: Elevating biological models of ... 的推薦與評價
Epithelial-to-mesenchymal transition (EMT), important in many ... in the involvement of EMT and MET in cancer progression and metastasis. ... <看更多>