關於 guanylate cyclase ，我們在網路上蒐集到這些相關的討論、資訊與評價

#11. Stimulators and Activators of Soluble Guanylate Cyclase

The heme-protein soluble guanylyl cyclase (sGC) is the intracellular receptor for nitric oxide (NO). sGC is a heterodimeric enzyme with α and β subunits and ...

#12. Nitric oxide activation of guanylyl cyclase in cells revisited

Nitric oxide (NO) elicits physiological effects in cells largely by activating guanylyl cyclase (GC)-coupled receptors, leading to cGMP ...

#13. Guanylate cyclase-C as a therapeutic target in ... - Gut

Recent studies have shown that membrane-bound guanylate cyclase-C (GC-C) receptors lining the GI tract may serve as novel therapeutic targets in the treatment ...

#14. Biochemistry, Guanylate Cyclase Article - StatPearls

Nitric oxide binds to its intracellular receptor soluble guanylyl cyclase (sGP) and increases cGMP levels. Nitric oxide binds to a heme ...

#15. Guanylate Cyclase inhibitor - Selleck Chemicals

ODQ (1H-ODQ) is a potent and selective inhibitor of soluble guanylyl cyclase (sGC, nitric oxide-activated enzyme) that enhances the pro-apoptotic effects of ...

#16. Nitric oxide (NO)-sensitive (soluble) guanylyl cyclase

Nitric oxide (NO)-sensitive (soluble) guanylyl cyclase in the IUPHAR/BPS Guide to PHARMACOLOGY.

#17. How Do Guanylate Cyclase-C Agonists Work? - RxList

Guanylate cyclase -C agonists are a class of medications used to treat constipation associated with irritable bowel syndrome (IBS) and ...

#18. 6JT2: Structure of human soluble guanylate cyclase in the NO ...

Soluble guanylate cyclase (sGC) is the primary sensor of nitric oxide. It has a central role in nitric oxide signalling and has been ...

#19. Soluble Guanylate Cyclase Stimulators | Drug, OTCs & Herbals

Soluble Guanylate Cyclase Stimulators: Dosing, Uses, Side Effects, Interactions, Patient Handouts, Pricing and more from Medscape Reference.

#20. Structure and Regulation of Soluble Guanylate Cyclase

Structure and Regulation of Soluble Guanylate Cyclase. Annual Review of Biochemistry. Vol. 81:533-559 (Volume publication date July 2012)

#21. Guanylate Cyclase Activity and Sperm Function

In species with external fertilization, the guanylate cyclase family is responsible for the long-distance interaction between gametes, ...

#22. Guanylate Cyclase | Activators Agonists | MedChemExpress

Guanylate cyclase (guanylyl cyclase, GC), which catalyzes the formation of cGMP from GTP, exists in both the soluble and particulate fractions of cells.

#23. List of Guanylate cyclase-C agonists - Drugs.com

Compare guanylate cyclase-C agonists. View important safety information, ratings, user reviews, popularity and more.

#24. Allosteric activation of the nitric oxide receptor soluble ... - eLife

Soluble guanylate cyclase (sGC) is the primary receptor for nitric oxide (NO) in mammalian nitric oxide signaling.

#25. Molecular basis for GTP recognition by light‐activated ...

Guanylate cyclases (GCs) convert guanosine 5′-triphosphate (GTP) into ... All GCs belong to the class III nucleotidyl cyclase (NC) family ...

#26. Crystal Structures of the Catalytic Domain of Human Soluble ...

Soluble guanylate cyclase (sGC) catalyses the synthesis of cyclic GMP in response to nitric oxide. The enzyme is a heterodimer of homologous ...

#27. Information on EC 4.6.1.2 - guanylate cyclase - BRENDA ...

Information on EC 4.6.1.2 - guanylate cyclase. ... alpha1 sGC, alpha1 soluble guanylyl cyclase, alpha1beta1 guanylyl cyclase, alpha1beta1 sGC, ANF-RGC, ...

#28. Current Modulation of Guanylate Cyclase Pathway Activity ...

In mammals, there are two key types of guanylate cyclases (GC), classified according to localization of enzymes in the cell. The first is called guanylate ...

#29. Soluble Guanylate Cyclase Inhibitors for HFpEF - NEJM ...

Soluble guanylate cyclase stimulators — not yet approved by the FDA — enhance cGMP production and sensitivity to endogenous nitrates, ...

#30. Soluble guanylate cyclase in NO signaling transduction - De ...

Soluble guanylate cyclase (sGC), as a sensor and receptor of NO, catalyzes the conversion of GTP to cGMP; the cGMP is a second messenger and ...

#31. Human soluble guanylate cyclase as a nitric oxide sensor for ...

Human soluble guanylate cyclase (hsGC), a NO sensor/NO receptor of a heterodimeric hemoprotein, plays a critical role in the NO-sGC-cGMP signaling pathway, ...

#32. Soluble guanylate cyclase agonists: Have we found a new ...

An emerging therapeutic target for HF is the nitric oxide-soluble guanylate cyclase-cyclic guanosine monophosphate (NO-sGC-cGMP) pathway, with newer agents ...

#33. EDRF Is a Ubiquitous Activator of Soluble Guanylate Cyclase1

Hormonal Regulation of the Different Isoforms of Guanylate Cyclase: EDRF Is a Ubiquitous Activator of Soluble Guanylate Cyclase1.

#34. Soluble Guanylate Cyclase Generation of cGMP Regulates ...

Pharmacological inhibition of soluble guanylate cyclase and NOS activity rapidly induces neurite retraction of MGE cells in vitro and in ...

#35. Receptor-type guanylate cyclase Gyc76C precursor - UniProt

Guanylate cyclase involved in the production of the second messenger cGMP (PubMed:24284209). Acts as a receptor for the NPLP1-4 peptide and modulates the ...

#36. Guanylate Cyclase C Agonists - Gastroenterology

guanylate cyclase C (GC-C) receptor agonist that results in water and elec- trolyte secretion and diarrhea. The GC-C receptor is a membrane-spanning pro-.

#37. Guanylate Cyclase inhibitors - AdooQ® Bioscience

Olinciguat (IW-1701) is an oral guanylate cyclase (sGC) stimulator with concentration-dependent stimulation of sGC in purified rat and human enzyme assays ...

#38. Anti-Guanylate Cyclase 2E Antibody, clone 8A5 - Sigma-Aldrich

Guanylyl cyclase GC-E (UniProt: P52785; also known as EC: 4.6.1.2, Guanylate cyclase 2E, GC-2E) is encoded by the Gucy2e (also known as Guc2e) gene (Gene ...

#39. Soluble Guanylate Cyclase - The Marletta Laboratory

Soluble guanylate cyclase (sGC) is the primary cellular NO receptor. sGC converts GTP to the secondary messenger cGMP. NO produced by the enzyme nitric ...

#40. Guanylate Cyclase | SpringerLink

Guanylyl cyclase The concept of second messenger molecules in hormone signal transduction was developed in the 1950s by Earl W. Sutherland ...

#41. Effect of Guanylate Cyclase-C Activity on Energy and Glucose ...

Uroguanylin and its transmembrane receptor guanylate cyclase-C (GC-C or GUCY2C) are predominantly found in intestinal epithelial cells and function to ...

#42. Guanylate Cyclase - 第 9 頁 - Google 圖書結果

This highly specific antibody was used to probe the features of the guanylate cyclase . The antibody blocked almost all of the guanylate cyclase activity of ...

#43. Ca2+ and Ca2+-interlocked Membrane Guanylate Cyclase ...

The properties of ANF-RGC also resolved the earlier erroneous conclusions on the nature of the membrane guanylate cyclase (Goldberg and Haddox, 1977; ...

#44. Guanylyl Cyclases and Signaling by Cyclic GMP

ANPCRs are homodimeric truncated guanylyl cyclases that possess extracellular ligand binding, transmembrane, and juxtamembrane domains but lack ...

#45. Guanylate Cyclase - Others - Signaling Pathways - APExBIO

Guanylate Cyclase. GC (guanylyl cyclaese) converts GTP into cGMP and pyrophosphate. sGC (soluble GC) is a nitric oxide receptor and pGC (transmembrance GC) ...

#46. Therapeutic potential of soluble guanylate cyclase modulators ...

Although stimulation of the nitric oxide (NO)-soluble guanylate cyclase (sGC)-cGMP signal transduction pathway has significant beneficial effects on disease ...

#47. Guanylate Cyclase-C Agonists for IBS-C - Pharmacy Times

Experts break down the appropriate use of guanylate cyclase-C agonists for irritable bowel syndrome with constipation (IBS-C).

#48. Anti-fibrotic effects of soluble guanylate cyclase stimulators ...

1.1 The NO-sGC-cGMP pathway. The nitric oxide (NO)-soluble guanylate cyclase (sGC)-cyclic guanosine monophosphate (cGMP) pathway, an important ...

#49. OMIM Entry - * 601330 - GUANYLATE CYCLASE 2C; GUCY2C

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#50. Soluble vs membrane guanylate cyclase. Upper panel

Guanylate cyclases are part of the G-protein signaling cascade, which is inhibited by high intracellular calcium levels but activated by low calcium levels 51, ...

#51. Stimulators and activators of soluble guanylate cyclase

The heme-containing enzyme, soluble guanylyl cyclase (sGC), is the intracellular receptor for nitric oxide (NO).

#52. Impact of oral soluble guanylate cyclase stimulators in patients ...

Soluble guanylate cyclase (sGC) stimulators are a novel class of medications with emerging role in heart failure (HF). The aim of this study to ...

#53. Axonal wiring of guanylate cyclase-D-expressing olfactory ...

Axonal wiring of guanylate cyclase-D-expressing olfactory neurons is dependent on neuropilin 2 and semaphorin 3F. Andreas Walz,.

#54. Evaluating Soluble Guanylate Cyclase Stimulation for Serious ...

Evaluating Soluble Guanylate Cyclase Stimulation for Serious Central Nervous System Diseases · In quantitative EEG studies, the CNS-penetrant sGC stimulator IW- ...

#55. sGC stimulators - Heart Failure Matters

Soluble Guanylate Cyclase (also termed Guanylyl Cyclase) stimulators (sGCS) and activators reduce oxidative stress by increasing levels of nitric oxide in ...

#56. The nitric oxide-guanylate cyclase pathway and glaucoma.

The nitric oxide - guanylyl cyclase-1 - cyclic guanylate monophosphate (NO-GC-1-cGMP) pathway has emerged as a potential pathogenic ...

#57. Plecanatide, a Guanylate Cyclase-C Agonist with Anti ...

Plecanatide acetate is a potent guanylate cyclase-C agonist, and turns out to have significant anti-inflammatory effect on inflammatory ...

#58. Discovery of Linaclotide - Ironwood Pharmaceuticals

Linaclotide was discovered as a result of Ironwood's pioneering research on the intestinal enzyme guanylate cyclase-C (GC-C) and went on to become the first ...

#59. Emergence of Novel Therapies for the Management of HFrEF

Determine the role of soluble guanylate cyclase (sGC) modulators in current and future treatment paradigms for heart failure. Apply the most ...

#60. Heart failure - Symptoms and causes - Mayo Clinic

... randomized, double-blind, placebo-controlled trial of the efficacy and safety of the oral soluble guanylate cyclase stimulator.

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guanylate cyclase stimulators or blood pressure medications, as these can cause an unsafe dip in blood pressure that can lead to fainting; alpha-blockers for ...

#62. Sildénafil : substance active à effet thérapeutique - VIDAL

L'oxyde d'azote active alors l'enzyme guanylate cyclase, ce qui entraîne une augmentation des concentrations de guanosine monophosphate ...

#63. 바이엘 만성 심부전 치료제 '베르쿠보' 국내 허가 ... - 메디포뉴스

이와 달리 베르쿠보는 수용성 구아닐산 고리화효소(soluble Guanylate Cyclase, 이하 sGC) 자극제로 심장 수축, 혈관 긴장도, 심장 재형성 등을 조절 ...

#64. 바이엘, 베르쿠보® 국내 허가 - 이엠디

이와 달리 베르쿠보 ® 는 수용성 구아닐산 고리화효소(soluble Guanylate Cyclase, 이하 sGC) 자극제로 심장 수축, 혈관 긴장도, 심장 재형성 등을 조절 ...

#65. Soluble Guanylate Cyclase Markt-Analyse Mit Key Playern ...

Soluble Guanylate Cyclase Markt-Analyse Mit Key Playern, Anwendungen, Trends Und Prognosen Bis 2028. Adelina Brown November 26, 2021 4 min read.

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#68. BlueChew: Sildenafil & Tadalafil Chewable ED Treatments

Do not take Sildenafil (sildenafil citrate) or Tadalafil if you take medication containing nitrates or guanylate cyclase stimulators for pulmonary ...

#69. La Guanylate Cyclase Soluble Analyse des performances ...

Le rapport Global La Guanylate Cyclase Soluble Market est un rapport complet, professionnel et approfondi développé en collectant des données ...

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Medicines called guanylate cyclase stimulators such as Adempas® (riociguat); Medicines called alpha-blockers such as Hytrin® (terazosin HCl), Flomax® ( ...

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베르쿠보는 수용성 구아닐산 고리화효소(soluble Guanylate Cyclase, 이하 sGC) 자극제로 심장 수축, 혈관 긴장도, 심장 재형성 등을 조절하는 세포내 ...

#72. Pulmonary Arterial Hypertension Treatment Market ...

Soluble Guanylate Cyclase (SGC) Stimulator. By Application: Hospital Pharmacies; Retail Pharmacies; Online Pharmacies. Top Companies Profiles:.

#73. Buy Sildenafil (Generic for Viagra®), Prescribed Online | hims

take any medicines called nitrates, often prescribed for chest pain, or guanylate cyclase stimulators like Adempas (riociguat) for pulmonary hypertension.

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... dendroaspis NP and urodilatin, with NP receptor-A (guanylate cyclase-A), NP receptor-B (guanylate cyclase-B) and NP receptor-C (clearance receptor).

#75. Soluble Guanylate Cyclase Trends, Wachstum, Umfang ...

Der neueste Jahresbericht zum Soluble Guanylate Cyclase-Markt bietet einen detaillierten Einblick in die Treiber, Einschränkungen und Chancen, ...

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... GRK · Imidazoline Receptor · GPCR19 · Guanylate Cyclase · TSH Receptor · CCK receptor · PKD · Leukotriene · Prostaglandin Receptor · Taste Receptor.

#77. Three-Way Valves Market 2021 Competitive Landscape, Key ...

... Phosphodiesterase-5 (PDE-5) inhibitors , Soluble guanylate cyclase (sGC) stimulators) by Applications (Early-stage Drug Candidates ...

#78. 高血壓與心血管 - Quizlet

分：Guanylate cyclase上升cGMP上升副：反射性心搏過速、潮紅禁：不與PDE-5 inhibitor並用、RV infarct. Digoxin. 分：抑制Na K pump、提升Ca濃度副：低血鉀、高血鈣、 ...

#79. Merck: Beneath The Surface - PharmaLive

... Merck also entered into a worldwide collaboration with Bayer to develop and commercialize soluble guanylate cyclase (sGC) modulators.

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#81. ERCİYES ÜNİVERSİTESİ VETERİNER FAKÜLTESİ DERGİSİ

coronary arterial guanylate cyclase by nitric oxide, nitroprusside and a carcinogenic nitrosamine. J. Cyclic Nucleotide Res 1979; 5: 211-44.

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Learning patterns that indicate that a network intrusion has occurred 4 A spring with force constant 0. has intrinsic Guanylate cyclase activity 3.

#83. Glyconutritional Supplements Market Covid-19 Impact In ...

The latest business intelligence report on Soluble Guanylate Cyclase market houses actionable insights into the key trends and opportunities ...

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Objective: To determine the optimal dose and tolerability of vericiguat, a soluble guanylate cyclase stimulator, in patients with worsening ...

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용해성 Guanylate Cyclase (SGC) 자극기. 최종 사용자 / 애플리케이션으로 폐 고혈압 치료제 시장 보고서는 다음 세그먼트를 커버 :.

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Runcaciguat (BAY 1101042) is an orally active stimulator of soluble guanylate cyclase, and is used in the research of cardiovascular and ...

#87. VIAGRA - Sildénafil - Posologie - Doctissimo

L'administration concomitante d'inhibiteurs de PDE5, tel que le sildénafil, avec les stimulateurs de la guanylate cyclase, tel que le riociguat, ...

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Stimulateur soluble de guanylate cyclase (SGC). 1.2 Analyse de l'industrie par applications: Pharmacies hospitalières Pharmacies de

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Previous work identified genes contributing to the evolutionary success of WS, in particular the di-guanylate Diguanylate cyclase WspR WT (Addgene #79162, ...